Reaction Details Report a problem with these data
Target
Glutathione reductase, mitochondrial
Ligand
BDBM501866
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>100000000±n/a nM
Citation
 Pelcman, B; Suna, E; Stafford, W; Priede, M Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer US Patent  US11028067 Publication Date 6/8/2021 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM501866
Synonyms:
US11028067, Example 7
Type:
Small organic molecule
Emp. Form.:
C10H9N3O5S2
Mol. Mass.:
315.326
SMILES:
COc1ccc(c(n1)S(=O)(=O)c1nc(C)cs1)[N+]([O-])=O
Structure:
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