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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502010
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
63.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502010
Synonyms:
US11028083, Example 6a
Type:
Small organic molecule
Emp. Form.:
C20H34F2N4O
Mol. Mass.:
384.507
SMILES:
CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@](C)(COC)CC1 |r,wU:20.23,17.18,wD:20.22,(7.44,7.29,;6.1,8.06,;4.77,7.29,;3.44,8.06,;2.1,7.29,;2.1,5.75,;.77,8.06,;-.56,7.29,;-.01,5.85,;-1.21,4.88,;-1.61,3.4,;-3.15,3.32,;-3.15,1.78,;-4.48,2.55,;-3.7,4.75,;-2.5,5.72,;-2.1,7.21,;-3.44,7.98,;-4.77,7.21,;-6.1,7.98,;-6.1,9.52,;-7.44,8.75,;-6.1,11.06,;-4.77,11.83,;-3.44,11.06,;-4.77,10.29,;-3.44,9.52,)|
Structure:
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