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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502061
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
134±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502061
Synonyms:
N-ethyl-1-methyl-4-(2- ((methyl(2-(methyl- amino)ethyl)amino)- methyl)-5,6-dihydro- 4H-pyrrolo[1,2-b]- pyrazol-3-yl)cyclo- hexane-1-carboxamide | US11028083, Example 55
Type:
Small organic molecule
Emp. Form.:
C21H37N5O
Mol. Mass.:
375.5514
SMILES:
CCNC(=O)C1(C)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12 |(-2.1,3.07,;-3.44,2.3,;-4.77,3.07,;-6.1,2.3,;-7.44,3.07,;-6.1,.76,;-7.44,-.01,;-4.77,1.53,;-3.44,.76,;-3.44,-.78,;-4.77,-1.55,;-6.1,-.78,;-2.1,-1.55,;-.56,-1.55,;.77,-.78,;2.1,-1.55,;2.1,-3.09,;3.44,-.78,;4.77,-1.55,;6.1,-.78,;7.44,-1.55,;-.09,-3.01,;-1.33,-3.92,;-1.81,-5.38,;-3.35,-5.38,;-3.83,-3.92,;-2.58,-3.01,)|
Structure:
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