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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502082
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
174±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502082
Synonyms:
US11028083, Example 69a
Type:
Small organic molecule
Emp. Form.:
C22H38N4O2
Mol. Mass.:
390.5627
SMILES:
CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CCC2(CC(C)(C)CO2)CC1 |r,wU:16.17,(8.05,-.64,;6.71,.13,;5.38,-.64,;4.05,.13,;2.71,-.64,;2.71,-2.18,;1.38,.13,;.05,-.64,;.52,-2.11,;-.72,-3.01,;-.88,-4.54,;-2.29,-5.17,;-3.54,-4.27,;-3.38,-2.73,;-1.97,-2.11,;-1.49,-.64,;-2.83,.13,;-4.16,-.64,;-5.49,.13,;-5.49,1.67,;-5.49,3.21,;-6.96,3.68,;-8.05,4.77,;-6.56,5.17,;-7.86,2.44,;-6.96,1.19,;-4.16,2.44,;-2.83,1.67,)|
Structure:
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