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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503307
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
2700±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503307
Synonyms:
6-amino-2-{9-amino-3- azabicyclo[3.3.1]nonan-3-yl}-5- (2,3-dichlorophenyl)-pyrimidine-4- carboxamide | US11033547, Compound 6 | US11696916, Compound 6
Type:
Small organic molecule
Emp. Form.:
C19H22Cl2N6O
Mol. Mass.:
421.324
SMILES:
NC1C2CCCC1CN(C2)c1nc(N)c(c(n1)C(N)=O)-c1cccc(Cl)c1Cl |THB:10:8:3.5.4:1,(7.14,-3.84,;5.94,-2.88,;4.37,-2.49,;4.37,-.67,;3.52,.68,;5.01,.28,;5.01,-1.46,;3.76,-1.95,;2.19,-1.55,;2.96,-2.88,;.86,-.78,;.86,.76,;-.48,1.53,;-.48,3.07,;-1.81,.76,;-1.81,-.78,;-.48,-1.55,;-2.9,-1.87,;-2.31,-3.29,;-4.44,-1.87,;-3.14,1.53,;-3.14,3.07,;-4.48,3.84,;-5.81,3.07,;-5.81,1.53,;-7.14,.76,;-4.48,.76,;-4.48,-.78,)|
Structure:
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