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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503310
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1100±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503310
Synonyms:
6-Amino-2-(4-amino-4-methyl- piperidin-1-yl)-5-(2,3-dichloro- phenyl)-pyrimidine-4-carboxylic acid methylamide | US11033547, Compound 9 | US11696916, Compound 9
Type:
Small organic molecule
Emp. Form.:
C18H22Cl2N6O
Mol. Mass.:
409.313
SMILES:
CNC(=O)c1nc(nc(N)c1-c1cccc(Cl)c1Cl)N1CCC(C)(N)CC1 |(-6.08,-1.95,;-4.74,-1.18,;-3.41,-1.95,;-3.41,-3.49,;-2.08,-1.18,;-.74,-1.95,;.59,-1.18,;.59,.36,;-.74,1.13,;-.74,2.67,;-2.08,.36,;-3.41,1.13,;-4.74,.36,;-6.08,1.13,;-6.08,2.67,;-4.74,3.44,;-4.74,4.98,;-3.41,2.67,;-2.08,3.44,;1.92,-1.95,;1.92,-3.49,;3.26,-4.26,;4.59,-3.49,;6.08,-3.09,;4.99,-4.98,;4.59,-1.95,;3.26,-1.18,)|
Structure:
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