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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503346
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
5500±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503346
Synonyms:
2-(2-Aminomethyl-azetidin-1-yl)-5- (2,3-dichloro-phenyl)-6-methyl- pyrimidine-4-carboxylic acid amide | US11033547, Compound 46 | US11696916, Compound 46
Type:
Small organic molecule
Emp. Form.:
C16H17Cl2N5O
Mol. Mass.:
366.245
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC1CN |(-1.21,-2.97,;-.44,-1.63,;1.1,-1.63,;1.87,-.3,;1.1,1.03,;-.44,1.03,;-1.21,2.37,;-2.75,2.37,;-.44,3.7,;-1.21,-.3,;-2.75,-.3,;-3.52,1.03,;-5.06,1.03,;-5.83,-.3,;-5.06,-1.63,;-5.83,-2.97,;-3.52,-1.63,;-2.75,-2.97,;3.41,-.3,;4.5,.79,;5.59,-.3,;4.5,-1.39,;4.5,-2.93,;5.83,-3.7,)|
Structure:
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