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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503366
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
6200±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503366
Synonyms:
2-(3,9-Diaza-bicyclo[4.2.1]-non-3- yl)-5-(2,3-dichloro-phenyl)-6- methyl-pyrimidine-4-carboxylic acid amide | US11033547, Compound 68 | US11696916, Compound 68
Type:
Small organic molecule
Emp. Form.:
C19H21Cl2N5O
Mol. Mass.:
406.309
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2CCC(C1)N2 |(-2.22,-3.33,;-1.45,-2,;.09,-2,;.86,-.67,;.09,.67,;-1.45,.67,;-2.22,2,;-1.45,3.33,;-3.76,2,;-2.22,-.67,;-3.76,-.67,;-4.53,.67,;-6.07,.67,;-6.84,-.67,;-6.07,-2,;-6.84,-3.33,;-4.53,-2,;-3.76,-3.33,;2.4,-.67,;2.97,-2,;4.5,-2.77,;5.59,-1.76,;6.84,-.86,;6.36,.61,;4.82,.61,;2.8,.82,;4.35,-.86,)|
Structure:
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