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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503382
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
6300±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503382
Synonyms:
2-((3S,4S)-3-Amino-4-hydroxy- pyrrolidin-1-yl)-5-(2,3-dichloro- phenyl)-6-methyl-pyrimidine-4- carboxylic acid amide | US11033547, Compound 84 | US11696916, Compound 84
Type:
Small organic molecule
Emp. Form.:
C16H17Cl2N5O2
Mol. Mass.:
382.244
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1C[C@H](N)[C@@H](O)C1 |r,wU:22.24,wD:20.22,(-1.81,-3.33,;-1.04,-2,;.5,-2,;1.27,-.67,;.5,.67,;-1.04,.67,;-1.81,2,;-3.35,2,;-1.04,3.33,;-1.81,-.67,;-3.35,-.67,;-4.12,.67,;-5.66,.67,;-6.43,-.67,;-5.66,-2,;-6.43,-3.33,;-4.12,-2,;-3.35,-3.33,;2.81,-.67,;3.72,.58,;5.18,.1,;6.43,1.01,;5.18,-1.44,;6.43,-2.34,;3.72,-1.91,)|
Structure:
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