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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM504027
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.026±n/a nM
Citation
 Chan, B; Daniels, B; Drobnick, J; Gazzard, L; Heffron, T; Huestis, M; Liang, J; Malhotra, S; Mendonca, R; Rajapaksa, N; Siu, M; Stivala, C; Tellis, J; Wang, W; Wei, B; Zhou, A; Cartwright, MW; Gancia, E; Jones, G; Lainchbury, M; Madin, A; Seward, E; Favor, D; Fong, KC; Good, A; Hu, Y; Hu, B; Lu, A Naphthyridines as inhibitors of HPK1 US Patent  US11034692 Publication Date 6/15/2021 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM504027
Synonyms:
(1S,2S)—N-[8-amino-6-(2,6-dichlorophenyl)-2,7-naphthyridin-3-yl]-2-[1-[2-(2-aminoethoxy)ethyl]-1H-pyrazol-4-yl]cyclopropane-1-carboxamide (Compound 295) and (1R,2R)—N-[8-amino-6-(2,6-dichlorophenyl)-2,7-naphthyridin-3-yl]-2-[1-[2-(2-aminoethoxy)ethyl]-1H-pyrazol-4-yl]cyclopropane-1-carboxamide | US11034692, Compound 296
Type:
Small organic molecule
Emp. Form.:
C25H25Cl2N7O2
Mol. Mass.:
526.418
SMILES:
NCCOCCn1cc(cn1)[C@@H]1C[C@H]1C(=O)Nc1cc2cc(nc(N)c2cn1)-c1c(Cl)cccc1Cl |r|
Structure:
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