Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM504423
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
200±n/a nM
Citation
 Crew, AP; Araujo, E Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides US Patent  US11065231 Publication Date 7/20/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM504423
Synonyms:
N-(5-((4-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3- dioxoisoindolin-5- yl)oxy)ethoxy)ethyl)piperazin- 1-yl)methyl)-1-((1s,4s)-4- methylcyclohexyl)-1H- benzo[d]imidazol-2-yl)-3- (trifluoromethyl)benzamide | US11065231, Example 7
Type:
Small organic molecule
Emp. Form.:
C44H48F3N7O7
Mol. Mass.:
843.8898
SMILES:
C[C@H]1CCC(CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12 |r,wU:1.0,(-9.75,-3.89,;-9.27,-2.42,;-10.3,-1.28,;-9.83,.19,;-8.32,.51,;-7.29,-.64,;-7.77,-2.1,;-7.85,1.97,;-8.75,3.22,;-10.29,3.22,;-11.06,4.55,;-10.29,5.88,;-12.6,4.55,;-13.37,3.22,;-14.91,3.22,;-15.68,4.55,;-14.91,5.88,;-13.37,5.88,;-15.68,7.22,;-17.22,7.22,;-16.45,8.55,;-14.91,8.55,;-7.85,4.46,;-6.38,3.99,;-5.05,4.76,;-3.71,3.99,;-2.38,4.76,;-1.05,3.99,;-1.05,2.45,;.29,1.68,;1.62,2.45,;2.95,1.68,;4.29,2.45,;5.62,1.68,;6.96,2.45,;8.29,1.68,;9.62,2.45,;10.96,1.68,;12.29,2.45,;13.62,1.68,;13.62,.14,;14.77,-.89,;16.27,-.57,;14.14,-2.3,;14.91,-3.63,;16.45,-3.63,;17.22,-4.97,;16.45,-6.3,;17.22,-7.64,;14.91,-6.3,;14.14,-4.97,;12.6,-4.97,;12.71,-2.28,;11.58,-3.28,;12.29,-.63,;10.96,.14,;1.62,3.99,;.29,4.76,;-3.71,2.45,;-5.05,1.68,;-6.38,2.45,)|
Structure:
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