Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM504438
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
650±n/a nM
Citation
 Crew, AP; Araujo, E Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides US Patent  US11065231 Publication Date 7/20/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM504438
Synonyms:
4-((1r,4r)-4-(4-(2-(2-((2- (2,6-dioxopiperidin-3-yl)- 1,3-dioxoisoindolin-5- yl)oxy)ethoxy)ethyl)piperazin- 1- yl)cyclohexyl)amino) quinazoline-6-carbonitrile | US11065231, Example 30
Type:
Small organic molecule
Emp. Form.:
C36H40N8O6
Mol. Mass.:
680.7528
SMILES:
O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCN3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12 |r,wU:28.29,wD:31.36,(11.01,7.56,;10.54,6.09,;11.44,4.85,;12.98,4.85,;13.75,6.18,;15.29,6.18,;16.06,4.85,;17.6,4.85,;15.29,3.51,;13.75,3.51,;12.98,2.18,;10.54,3.6,;11.01,2.13,;9.07,4.08,;7.74,3.31,;6.4,4.08,;5.07,3.31,;3.74,4.08,;2.4,3.31,;1.07,4.08,;-.26,3.31,;-1.6,4.08,;-2.93,3.31,;-2.93,1.77,;-4.26,1,;-5.6,1.77,;-5.6,3.31,;-4.26,4.08,;-6.93,1,;-6.93,-.54,;-8.27,-1.31,;-9.6,-.54,;-9.6,1,;-8.27,1.77,;-10.93,-1.31,;-10.93,-2.85,;-9.6,-3.62,;-9.6,-5.16,;-10.93,-5.93,;-12.27,-5.16,;-13.6,-5.93,;-14.93,-5.16,;-14.93,-3.62,;-13.6,-2.85,;-12.27,-3.62,;-16.27,-2.85,;-17.6,-2.08,;6.4,5.62,;7.74,6.39,;9.07,5.62,)|
Structure:
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