Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM404386
Substrate
n/a
Meas. Tech.
Biochemical Fluorescence Intensity Kinetic Assay
IC50
<100±n/a nM
Citation
 Jones, A; Kemp, M; Stockley, M; Gibson, K; Whitlock, G 1-cyano-pyrrolidine compounds as USP30 inhibitors US Patent  US11066365 Publication Date 7/20/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM404386
Synonyms:
(R)-4-(3-chloropyridin-4-yl)-N- (1-cyanopyrrolidin-3-yl)-3- methoxybenzamide | US10343992, Example 39 | US10689345, Example 39 | US11066365, Example 39 | US11390584, Example 39
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4O2
Mol. Mass.:
356.806
SMILES:
COc1cc(ccc1-c1ccncc1Cl)C(=O)N[C@@H]1CCN(C1)C#N
Structure:
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