| Assay Method Information | |
| | In vitro MKP-3 Phosphatase Dose Response Active/Probe Assessment Assay - Reproducibility testing |
| Description: | The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibitors of actives identified in the MKP-3 HTS run at (Burham Institute) SDCCG center AID 425 and the MKP-1 HTS run at the PMLSC AID 374, and subsequently confirmed in the MKP-3 & MKP-1 HTS dose response confirmation assays AID's 553 & 551. The in vitro MKP-3 Phosphatase dose response hit/probe assessment reproducibility testing assay has been developed and run at the University of Pittsburgh Molecular Screening Center (PMLSC) part of the Molecular Library Screening Center Network (MLSCN). XO1 submission MH-76390 In vitro HTS assay for MKP-3, Assay Provider Dr. John S. Lazo, Department of Pharmacology at the University of Pittsburgh. The 107 protein tyrosine phosphatases (PTPs) found in the human genome are defined by the active site sequence C(X)5R(S/T), with X being any amino acid, and they are critical regulators of mammalian cell pr |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |