| Assay Method Information | |
| | Radioligand binding assay |
| Description: | Radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determined in membranes prepared from CHO cells expressing either the OX1 or OX2 receptor. The intrinsic orexin receptor antagonist activity of a compound which may be used in the present invention may be determined by these assays. |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |