Compile Data Set for Download or QSAR
Report error Found 407 of affinity data for UniProtKB/TrEMBL: O14492
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484440BDBM484440(US10934285, Example 24 | US12053470, Compound 47)
Affinity DataIC50: 1nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484457BDBM484457(US10934285, Example 43)
Affinity DataIC50: 1.5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504308BDBM504308(US11034705, Compound 17 | (3-((3S,4S)-4-amino-3-me...)
Affinity DataIC50: 2nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479344BDBM479344((3-((3S,4)S-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: 2.30nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479347BDBM479347((3-((S)-5-amino-5,7-dihydrospiro[cyclo- penta[b]py...)
Affinity DataIC50: 2.70nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484469BDBM484469(US10934285, Example 55)
Affinity DataIC50: 2.80nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484472BDBM484472(US10934285, Example 59)
Affinity DataIC50: 3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484421BDBM484421(US10934285, Example 5)
Affinity DataIC50: 3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484466BDBM484466(US10934285, Example 52)
Affinity DataIC50: 3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484461BDBM484461(US10934285, Example 47)
Affinity DataIC50: 3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479327BDBM479327((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: 3nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504292BDBM504292(US11034705, Compound 1 | (3-((3S,4S)-4-amino-3-met...)
Affinity DataIC50: 3nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479359BDBM479359((3-((S)-5-amino-5,7-dihydro- spiro[cyclopenta[b]py...)
Affinity DataIC50: 3.30nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479361BDBM479361((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...)
Affinity DataIC50: 3.5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479340BDBM479340((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: 3.60nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504343BDBM504343(US11034705, Compound 52 | (3-((3S,4S)-4-amino-3-me...)
Affinity DataIC50: 3.70nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479341BDBM479341((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: 3.80nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479357BDBM479357((S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-...)
Affinity DataIC50: 3.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504293BDBM504293(US11034705, Compound 2 | (3-((3S,4S)-4-amino-3-met...)
Affinity DataIC50: 4nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504323BDBM504323(US11034705, Compound 32 | (3-((3S,4S)-4-amino-3-me...)
Affinity DataIC50: 4nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479348BDBM479348((3-((S)-5-amino-5,7-dihydrospiro[cyclo- penta[b]py...)
Affinity DataIC50: 4.20nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479342BDBM479342((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: 4.20nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484467BDBM484467(US10934285, Example 53 | US12053470, Compound 46)
Affinity DataIC50: 4.40nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479354BDBM479354((3S,4S)-8-(5-(((6aS,8S)-8-(methoxymethyl)-6a,7,8,9...)
Affinity DataIC50: 4.5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484429BDBM484429(US10934285, Example 13 | US12053470, Compound 52)
Affinity DataIC50: 4.60nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504342BDBM504342(US11034705, Compound 51 | (3-((3S,4S)-4-amino-3-me...)
Affinity DataIC50: 4.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504295BDBM504295(US11034705, Compound 4 | (3-((3S,4S)-4-amino-3-met...)
Affinity DataIC50: 5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484439BDBM484439(US10934285, Example 23)
Affinity DataIC50: 5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484422BDBM484422(US10934285, Example 6)
Affinity DataIC50: 5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479352BDBM479352((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: 5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479325BDBM479325((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: 5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479349BDBM479349((3-((S)-5-amino-13-oxa-9- azadispiro[3.1.56.24]tri...)
Affinity DataIC50: 5.70nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479351BDBM479351((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50: 5.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479353BDBM479353((3S,4S)-8-(5-(((6aS,8S)-8-((methoxymethoxy)methyl)...)
Affinity DataIC50: 5.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479355BDBM479355((3S,4S)-8-(6-amino-5-(((6aS,8S)-8-((methoxymeth- o...)
Affinity DataIC50: 5.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484430BDBM484430(US10934285, Example 14 | US12053470, Compound 51)
Affinity DataIC50: 5.90nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484423BDBM484423(US10934285, Example 7 | US12053470, Compound 48)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479333BDBM479333((6aS,8S)-4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- ...)
Affinity DataIC50: 6nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504297BDBM504297(US11034705, Compound 6 | (3-((3S,4S)-4-amino-3-met...)
Affinity DataIC50: 6nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 504298BDBM504298(US11034705, Compound 7 | (6aS,8S)-4-((5-((3S,4S)-4...)
Affinity DataIC50: 6nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484419BDBM484419(US10934285, Example 3)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484451BDBM484451(US10934285, Example 37)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484426BDBM484426(US10934285, Example 10)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479345BDBM479345((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50: 6.20nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484470BDBM484470(US10934285, Example 56)
Affinity DataIC50: 6.60nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484425BDBM484425(US10934285, Example 9)
Affinity DataIC50: 7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 479350BDBM479350((3-((S)-5-amino-13-oxa-9- azadispiro[3.1.56.24]tri...)
Affinity DataIC50: 7nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484418BDBM484418(US10934285, Example 2 | US12053470, Compound 50)
Affinity DataIC50: 7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484459BDBM484459(US10934285, Example 45)
Affinity DataIC50: 7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 484468BDBM484468(US10934285, Example 54 | US12053470, Compound 54)
Affinity DataIC50: 7.30nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent

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