Compile Data Set for Download or QSAR
Report error Found 45 of affinity data for UniProtKB/TrEMBL: O55192
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014245BDBM50014245(6-Phenyl-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]iso...)
Affinity DataKi:  0.600nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50021879BDBM50021879(CHEMBL285506 | 6-(4-Chloro-phenyl)-1,2,3,5,6,10b-h...)
Affinity DataKi:  0.680nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014232BDBM50014232(CHEMBL330666 | 6-(4-Ethynyl-phenyl)-1,2,3,5,6,10b-...)
Affinity DataKi:  0.940nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50322698BDBM50322698(rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-aza...)
Affinity DataKi:  1.58nMAssay Description:Displacement of [3H]nisoxetine from NET in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014233BDBM50014233(CHEMBL94535 | 6-(2-Chloro-phenyl)-1,2,3,5,6,10b-he...)
Affinity DataKi:  1.60nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014237BDBM50014237(CHEMBL327790 | 6-(4-Methylsulfanyl-phenyl)-1,2,3,5...)
Affinity DataKi:  1.80nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014237BDBM50014237(CHEMBL327790 | 6-(4-Methylsulfanyl-phenyl)-1,2,3,5...)
Affinity DataKi:  2.90nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014237BDBM50014237(CHEMBL327790 | 6-(4-Methylsulfanyl-phenyl)-1,2,3,5...)
Affinity DataKi:  2.90nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014234BDBM50014234(CHEMBL96362 | 9-Chloro-6-(4-chloro-phenyl)-1,2,3,5...)
Affinity DataKi:  3.20nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014242BDBM50014242(CHEMBL94711 | 6-(2-Methoxy-phenyl)-1,2,3,5,6,10b-h...)
Affinity DataKi:  3.30nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014240BDBM50014240(CHEMBL94665 | 6-(2-Methylsulfanyl-phenyl)-1,2,3,5,...)
Affinity DataKi:  4.5nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014236BDBM50014236(CHEMBL539803 | 6-(4-Ethylsulfanyl-phenyl)-1,2,3,5,...)
Affinity DataKi:  6nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014241BDBM50014241(CHEMBL94738 | 6-(4-Trifluoromethyl-phenyl)-1,2,3,5...)
Affinity DataKi:  11nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014244BDBM50014244(CHEMBL555462 | 10-Methyl-6-(4-methylsulfanyl-pheny...)
Affinity DataKi:  12nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010859BDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataKi:  12nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014239BDBM50014239(CHEMBL329216 | 4-(1,2,3,5,6,10b-Hexahydro-pyrrolo[...)
Affinity DataKi:  14nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014224BDBM50014224(CHEMBL555655 | 8-Chloro-6-(4-methylsulfanyl-phenyl...)
Affinity DataKi:  16nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010859BDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataKi:  16nMAssay Description:Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014231BDBM50014231(CHEMBL94508 | 6-(2,4-Dichloro-phenyl)-1,2,3,5,6,10...)
Affinity DataKi:  17nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22416BDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataKi:  20nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014226BDBM50014226(CHEMBL554191 | 10-Chloro-6-(4-methylsulfanyl-pheny...)
Affinity DataKi:  23nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014243BDBM50014243(CHEMBL95153 | N-[4-(1,2,3,5,6,10b-Hexahydro-pyrrol...)
Affinity DataKi:  59nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014230BDBM50014230(CHEMBL93035 | 6-(4-Methanesulfonyl-phenyl)-1,2,3,5...)
Affinity DataKi:  79nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 30130BDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataKi:  85nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014225BDBM50014225(CHEMBL328818 | 4-(1,2,3,5,6,10b-Hexahydro-pyrrolo[...)
Affinity DataKi:  90nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014228BDBM50014228(CHEMBL541308 | 10-Bromo-6-(4-methylsulfanyl-phenyl...)
Affinity DataKi:  94nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014247BDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  120nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014246BDBM50014246(6-(4-Methylsulfanyl-phenyl)-1,2,3,5,6,10b-hexahydr...)
Affinity DataKi:  127nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017721BDBM50017721(5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclop...)
Affinity DataKi:  290nMAssay Description:Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014229BDBM50014229(CHEMBL545724 | 6-(4-Methylsulfanyl-phenyl)-1,2,3,5...)
Affinity DataKi:  390nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50014227BDBM50014227(CHEMBL96615 | 6-(4-Methanesulfinyl-phenyl)-1,2,3,5...)
Affinity DataKi:  723nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010307BDBM50010307(CHEMBL3251303)
Affinity DataIC50: 800nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010306BDBM50010306(CHEMBL3251302)
Affinity DataIC50: 800nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 77970BDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataIC50: 900nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25870BDBM25870(CITALOPRAM HYDROBROMIDE | [3H]Escitalopram | Escit...)
Affinity DataKi: >1.00E+3nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005246BDBM50005246(beta-aminopropylbenzene | AMPHETAMINE SULFATE | de...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 35229BDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50010305BDBM50010305(CHEMBL3251301)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22417BDBM22417(LY 94939 | Nisoxetine Inhibitor | Nisoxetine | LY1...)
Affinity DataKi:  7.05E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 35229BDBM35229(Desmethylimipramine | 3-(10,11-dihydro-5H-dibenzo[...)
Affinity DataKi:  8.11E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 35920BDBM35920(CHEMBL47482 | 9-(Aminomethyl)-9,10-dihydroanthrace...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063500BDBM50063500(CHEMBL3398506)
Affinity DataIC50: 4.27E+4nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cells by [3H]GABA uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063507BDBM50063507(CHEMBL3398507)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cells by [3H]GABA uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063513BDBM50063513(CHEMBL3398496)
Affinity DataIC50: 1.58E+5nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cells by [3H]GABA uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Mouse)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50063510BDBM50063510(CHEMBL3398494)
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cells by [3H]GABA uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed