Compile Data Set for Download or QSAR
Report error Found 10381 of affinity data for UniProtKB/TrEMBL: P04629
TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374725(US10246466, Example 75 | 12-fluoro-15-methyl-5,6,7...)
Affinity DataKd:  0.0150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374725(US10246466, Example 75 | 12-fluoro-15-methyl-5,6,7...)
Affinity DataKd:  0.0150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.0310nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.0310nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  0.0510nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  0.0510nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374722(US10246466, Example 51 | 11-fluoro-13-methyl-6,7,1...)
Affinity DataKd:  0.0650nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374722(US10246466, Example 51 | 11-fluoro-13-methyl-6,7,1...)
Affinity DataKd:  0.0650nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0670nMAssay Description:Based on HTRF of Cisbio (Cisbio, Cat. 08-52) principle, TRKA and ALK-L1196M kinase activity detection platform were established to determine the inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
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PDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM356152(US9815846, Compound 152 | 2-fluoro-5-(1-methyl-1H-...)
Affinity DataIC50: 0.0690nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
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TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374719(US10246466, Example 45 | 11-fluoro-14-(propan-2-yl...)
Affinity DataKd:  0.0820nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374719(US10246466, Example 45 | 11-fluoro-14-(propan-2-yl...)
Affinity DataKd:  0.0820nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM356096(US9815846, Compound 96 | N-(2-((2,5-dioxoimidazoli...)
Affinity DataIC50: 0.0830nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374718(US10246466, Example 43 | 14-ethyl-11-fluoro-6,7,13...)
Affinity DataKd:  0.0860nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374718(US10246466, Example 43 | 14-ethyl-11-fluoro-6,7,13...)
Affinity DataKd:  0.0860nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374717(US10246466, Example 42 | 10-fluoro-7-methyl-7,8,15...)
Affinity DataKd:  0.0880nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374717(US10246466, Example 42 | 10-fluoro-7-methyl-7,8,15...)
Affinity DataKd:  0.0880nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM50590818(CHEMBL5170096)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of TRKA F589L mutant (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM50590817(CHEMBL5170464)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of TRKA F589L mutant (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM50590823(CHEMBL5189971)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of TRKA F589L mutant (unknown origin) using TK-sub-biotin peptide as substrate incubated for 30 mins followed by treated with ATP and subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412264(US10399945, Example 9 | US10399945, Example 3 | US...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412269(US10399945, Example 8 | US10669239, Compound 8 | U...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412263(US10399945, Example 7 | US10399945, Example 2 | US...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412267(US10399945, Example 6 | US10669239, Compound 20 | ...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412266(US10399945, Example 18 | US10399945, Example 5 | U...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412265(US10399945, Example 10 | US10399945, Example 4 | U...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412264(US10399945, Example 9 | US10399945, Example 3 | US...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412263(US10399945, Example 7 | US10399945, Example 2 | US...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412262(US10399945, Example 1 | US10669239, Compound 1 | U...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412286(US10399945, Example 25 | US10669239, Compound 25 |...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412285(US10399945, Example 24 | US10669239, Compound 24 |...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412284(US10399945, Example 23 | US10669239, Compound 23 |...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412283(US10399945, Example 22 | US10669239, Compound 22 |...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM483555(US10927079, Compound 21)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412267(US10399945, Example 6 | US10669239, Compound 20 | ...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412280(US10399945, Example 19 | US10669239, Compound 19 |...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412266(US10399945, Example 18 | US10399945, Example 5 | U...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412278(US10399945, Example 17 | US10669239, Compound 17 |...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412277(US10399945, Example 16 | US10669239, Compound 16 |...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412276(US10399945, Example 15 | US10927079, Compound 15)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412275(US10399945, Example 14 | US10927079, Compound 14)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM483547(US10927079, Compound 13)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412273(US10399945, Example 12 | US10927079, Compound 12)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412272(US10399945, Example 11 | US10927079, Compound 11)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM50524981(CHEMBL4562879)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of N-terminal GST-tagged human TrkA kinase domain (436 to 790 residues) expressed in baculovirus expression system using biotin-poly-GT as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412265(US10399945, Example 10 | US10399945, Example 4 | U...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM483600(US10927079, Compound 37b)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM412300(US10399945, Example 37a | US10399945, Example 37 |...)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM483571(US10927079, Compound 37)
Affinity DataIC50: 0.100nMAssay Description:Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

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