Compile Data Set for Download or QSAR
Report error Found 268 of affinity data for UniProtKB/TrEMBL: P05091
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118233BDBM118233(US8673966, tert-butyl (1-(3-((3-(4-(methylsulfonam...)
Affinity DataIC50: 2.30nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093535BDBM50093535(11-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118229BDBM118229(US8673966, N-(4-(7-((1-(cyclobutanecarbonyl)azetid...)
Affinity DataIC50: 4nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093537BDBM50093537(10-(3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yloxy)d...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118196BDBM118196(US8673966, N-(4-(7-((1-methyl-1H-imidazol-5-yl)eth...)
Affinity DataIC50: 4.90nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118228BDBM118228(US8673966, N-(4-(7-((1-(2,2-difluorocyclopropane- ...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118232BDBM118232(US8673966, tert-butyl 1-(3-((3-(4- (methylsulfonam...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118223BDBM118223(US8673966, N-(4-(7-((1-(3-hydroxy-3-methylcyclobut...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118209BDBM118209(US8673966, N-(4-(7-((1-(cyclopropanecarbonyl)azeti...)
Affinity DataIC50: 5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118231BDBM118231(US8673966, tert-butyl 1-(3-((3-(4-(methylsulfonami...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118230BDBM118230(US8673966, N-(4-(7-((1-(1-methylcyclopropanecarbon...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118220BDBM118220(US8673966, N-(4-(7-((1-(3,3-difluorocyclobutanecar...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118225BDBM118225(US8673966, N-(4-(7-((1-(3-methyloxetane-3- carbony...)
Affinity DataIC50: 6nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118211BDBM118211(US8673966, N-(4-(7-((1-(cyclopropanecarbonyl)piper...)
Affinity DataIC50: 6.5nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118213BDBM118213(US8673966, N-(4-(7-((1-isopropyl-1H-imidazol-5- yl...)
Affinity DataIC50: 7nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118219BDBM118219(US8673966, N-(4-(7-((1-(3-methoxypropanoyl)azetidi...)
Affinity DataIC50: 8nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093534BDBM50093534(7-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093531BDBM50093531(6-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118216BDBM118216(US8673966, cyclopentyl 3-((3-(4- (methylsulfonamid...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118207BDBM118207(US8673966, tert-butyl 3-((3-(4-(methylsulfonamido)...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118208BDBM118208(US8673966, N-(4-(4-oxo-7-((2-oxo-1,2-dihydropyridi...)
Affinity DataIC50: 9nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118212BDBM118212(US8673966, N-(4-(7-((1,2-dimethyl-1H-imidazol-5- y...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118222BDBM118222(US8673966, N-(4-(7-((1-(2-hydroxyacetyl)azetidin-3...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118226BDBM118226(US8673966, N-(4-(7-((1-(2-hydroxypropanoyl)azetidi...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118224BDBM118224(US8673966, N-(4-(7-((1-(2-hydroxy-2-methylpropanoy...)
Affinity DataIC50: 16nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50236899BDBM50236899(CHEMBL4099822)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of full length recombinant human ALDH2 expressed in Escherichia coli assessed as reduction in dehydrogenase activity using pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118203BDBM118203(US8673966, N-(4-(4-oxo-7-(pyridin-3-ylethynyl)-4H-...)
Affinity DataIC50: 21nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 153687BDBM153687(US9000015, 4 | US10507215, Compound 4)
Affinity DataIC50: 23nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 153687BDBM153687(US9000015, 4 | US10507215, Compound 4)
Affinity DataIC50: 23nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 153690BDBM153690(US9000015, 7 | US9610299, Example 7 | US10507215, ...)
Affinity DataIC50: 23nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 153696BDBM153696(US9000015, 13 | US9610299, Example 13 | US10507215...)
Affinity DataIC50: 25nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 153696BDBM153696(US9000015, 13 | US9610299, Example 13 | US10507215...)
Affinity DataIC50: 25nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 153696BDBM153696(US9000015, 13 | US9610299, Example 13 | US10507215...)
Affinity DataIC50: 25nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50236900BDBM50236900(CHEMBL4072941)
Affinity DataKi:  35nMAssay Description:Non-competitive inhibition of full length recombinant human ALDH2 expressed in Escherichia coli assessed as reduction in dehydrogenase activity using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2019
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118227BDBM118227(US8673966, N-(4-(7-((1-(1-methylpiperidine-4- carb...)
Affinity DataIC50: 35nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50104892BDBM50104892(8-(3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yloxy)oc...)
Affinity DataIC50: 40nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093538BDBM50093538(7-Ethoxy-3-(4-hydroxy-phenyl)-chromen-4-one | 7-et...)
Affinity DataIC50: 40nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50104896BDBM50104896(7-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-(4-hydro...)
Affinity DataIC50: 40nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50409029BDBM50409029(DAIDZIN)
Affinity DataIC50: 40nMAssay Description:Inhibition of Hamster Liver mitochondrial ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093535BDBM50093535(11-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]...)
Affinity DataIC50: 40nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118217BDBM118217(US8673966, N-(4-(4-oxo-7-((tetrahydro-2H-pyran-4- ...)
Affinity DataIC50: 43nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118197BDBM118197(US8673966, N-(4-(7-(3-methoxyprop-1-ynyl)-4-oxo-4H...)
Affinity DataIC50: 47nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093534BDBM50093534(7-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093537BDBM50093537(10-(3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yloxy)d...)
Affinity DataIC50: 50nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50448802BDBM50448802(CHEMBL3128207)
Affinity DataIC50: 50nMAssay Description:Inhibition of human ALDH2 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118202BDBM118202(US8673966, N-(4-(4-oxo-7-(pyrimidin-5-ylethynyl)-4...)
Affinity DataIC50: 57nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 118193BDBM118193(US8673966, N-(4-(7-(cyclopropylethynyl)-4-oxo-4H- ...)
Affinity DataIC50: 57.7nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 50093531BDBM50093531(6-[3-(4-Hydroxy-phenyl)-4-oxo-4H-chromen-7-yloxy]-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of hamster liver aldehyde dehydrogenase ALDH-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 153684BDBM153684(US9000015, 1 | US9610299, Example 1 | US10507215, ...)
Affinity DataIC50: 63nMpH: 7.4Assay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
US Patent

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 153684BDBM153684(US9000015, 1 | US9610299, Example 1 | US10507215, ...)
Affinity DataIC50: 63nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

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