Compile Data Set for Download or QSAR
Report error Found 130 of affinity data for UniProtKB/TrEMBL: P07382
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataKi:  0.129nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataIC50: 2.29nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM585344(US11530198, Example 19 | 5-(4-(quinolin-3-yl)piper...)
Affinity DataIC50: 3.72nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM50531796(CHEMBL4544467 | US11530198, Example 12)
Affinity DataIC50: 7.41nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM50531791(CHEMBL4456834 | US11530198, Example 6)
Affinity DataIC50: 7.59nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM585318(US11530198, Example 110 | 5-(4-(3-(tetrahydro-2H-p...)
Affinity DataIC50: 7.94nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM50291790(1-[3-(Biphenyl-3-yloxymethyl)-phenyl]-6,6-dimethyl...)
Affinity DataKi:  17.0nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291769(6,6-Dimethyl-1-(3-nonyl-phenyl)-1,6-dihydro-[1,3,5...)
Affinity DataKi:  20.9nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50562454(TCMDC-141974 | CHEMBL533684)
Affinity DataIC50: 25nMAssay Description:Inhibition of Leishmania major DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM585324(US11530198, Example 98 | 5-(4-(3-(2-(azetidin-1- y...)
Affinity DataIC50: 28.8nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM50600679(CHEMBL426 | Methotrexate | TCMDC-123832 | TCMDC-12...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50531780(CHEMBL4464707 | US11530198, Example 73)
Affinity DataIC50: 36.3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM50291791(6,6-Dimethyl-1-[3-(naphthalen-1-yloxymethyl)-pheny...)
Affinity DataKi:  39.8nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM585346(US11530198, Example 90 | 5-(4-(3-(2-fluoropyridin-...)
Affinity DataIC50: 42.7nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM585345(US11530198, Example 107 | 5-(4-(3-(pyridazin-3- yl...)
Affinity DataIC50: 52.5nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

LigandPNGBDBM50291772(6,6-Dimethyl-1-[3-(2,4,5-trichloro-phenoxymethyl)-...)
Affinity DataKi:  69.2nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291803(1-(3-Dodecyl-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3...)
Affinity DataKi:  72.4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291778(N-{3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazi...)
Affinity DataKi:  75.9nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291805(6,6-Dimethyl-1-{3-[4-(3-trifluoromethyl-phenoxy)-b...)
Affinity DataKi:  75.9nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM18771(CHEMBL389051 | (2S)-2-[(4-{[(2-amino-4-oxo-1,4-dih...)
Affinity DataKi:  80nM ΔG°:  -39.8kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed
LigandPNGBDBM50291771({3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-...)
Affinity DataKi:  91.2nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50562449(CHEMBL4745475)
Affinity DataIC50: 100nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50291807(1-[3-(4-Chloro-benzylsulfanyl)-phenyl]-6,6-dimethy...)
Affinity DataKi:  110nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataKi:  120nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50291802(1-[3-(3-Ethyl-phenoxymethyl)-phenyl]-6,6-dimethyl-...)
Affinity DataKi:  126nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50562446(CHEMBL4752301)
Affinity DataIC50: 130nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50600690(CHEMBL5206994)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50562448(CHEMBL4779765)
Affinity DataIC50: 140nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50600691(CHEMBL5205559)
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50291783(1-[3-(3-Methoxy-phenoxymethyl)-phenyl]-6,6-dimethy...)
Affinity DataKi:  151nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291766(1-[3-(3-Isopropyl-phenoxymethyl)-phenyl]-6,6-dimet...)
Affinity DataKi:  174nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291782(3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  178nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50600702(CHEMBL5199171)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50562447(CHEMBL4761589)
Affinity DataIC50: 180nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50562442(CHEMBL4748158)
Affinity DataIC50: 190nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50562445(CHEMBL4748139)
Affinity DataIC50: 210nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50291804(1-(3-Benzylsulfanyl-phenyl)-6,6-dimethyl-1,6-dihyd...)
Affinity DataKi:  224nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291789(1-[3-(3-Chloro-phenoxymethyl)-phenyl]-6,6-dimethyl...)
Affinity DataKi:  224nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50600703(CHEMBL5201183)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50071576(CHEMBL3410463)
Affinity DataKd:  241nMAssay Description:Binding affinity to Leishmania major DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50562441(CHEMBL4791810)
Affinity DataIC50: 250nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50291797(6,6-Dimethyl-1-{3-[2-(3-trifluoromethyl-phenoxy)-e...)
Affinity DataKi:  251nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50398394(CHEMBL1232702)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50291768(6,6-Dimethyl-1-(3-phenylselanylmethyl-phenyl)-1,6-...)
Affinity DataKi:  275nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291784(6,6-Dimethyl-1-(3-nonyloxy-phenyl)-1,6-dihydro-[1,...)
Affinity DataKi:  302nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291787(xv6,6-Dimethyl-1-[3-(4-pentyl-phenoxymethyl)-pheny...)
Affinity DataKi:  339nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50562455(CHEMBL2005041)
Affinity DataIC50: 360nMAssay Description:Inhibition of Leishmania major DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50562438(CHEMBL4743204)
Affinity DataIC50: 380nMAssay Description:Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50291794(6,6-Dimethyl-1-(3-phenylsulfanylmethyl-phenyl)-1,6...)
Affinity DataKi:  407nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50291785(6,6-Dimethyl-1-(3-m-tolyloxymethyl-phenyl)-1,6-dih...)
Affinity DataKi:  427nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
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