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TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM81917(BX-2819)
Affinity DataIC50: 0.0400nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152279(US8993556, 3-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.0430nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152285(US8993556, N-[1-(4,4-Difluorocyclohexyl)piperidin-...)
Affinity DataKd:  0.0570nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50442757(CHEMBL2443026)
Affinity DataKd:  0.0570nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152280(US8993556, 3-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.0660nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152283(US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.0790nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152281(US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.0800nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152287(US8993556, N-(1-Cyclohexylpiperidin-4-yl)-5-{2-[4-...)
Affinity DataKd:  0.0900nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM81916(lspropyl analog, 5)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM81914(Ethyl carbamate analog, 3)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50442759(CHEMBL2443138)
Affinity DataKd:  0.120nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152284(US8993556, N-[1-(Cyclohexylmethyl)piperidin-4-yl]-...)
Affinity DataKd:  0.188nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50401333(CHEMBL1230584)
Affinity DataKi:  0.200nMAssay Description:Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM81915(Ethyl analog, 4)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50442758(CHEMBL2443139)
Affinity DataKd:  0.218nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152286(US8993556, 3-[2,4-Dihydroxy-6-(4-nitrophenoxy)phen...)
Affinity DataKd:  0.240nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50362225(CHEMBL1939381)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152277(US8993556, N-(1-Cyclohexylpiperidin-4-yl)-5-[2,4-d...)
Affinity DataKd:  0.300nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM81912(Resorcinol analog, 1 | DC23)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495248(CHEMBL3104281)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50442760(CHEMBL2443044)
Affinity DataKd:  0.350nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50362226(CHEMBL1939380)
Affinity DataKd:  0.380nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152282(US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.423nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495254(CHEMBL3104273)
Affinity DataKd:  0.430nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495250(CHEMBL3104277)
Affinity DataKd:  0.460nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50645078(CHEMBL5574581)
Affinity DataKd:  0.480nMAssay Description:Binding affinity to human N-terminal his tagged Hsp90alpha (1 to 241 residues) expressed in Escherichia coli (DE3) strain assessed as dissociation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495245(CHEMBL3104289)
Affinity DataKd:  0.480nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM81913(Unsubstituted phenyl ring analog, 2)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50362220(CHEMBL1939379)
Affinity DataKd:  0.520nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50482743(CHEMBL1215467)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to human N-terminal ATPase domain of Hsp90 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50593502(CHEMBL1215539)
Affinity DataKd:  0.540nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495244(CHEMBL3104276)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495243(CHEMBL3104280)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50362224(CHEMBL1939382)
Affinity DataKd:  0.610nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50362223(CHEMBL1939383)
Affinity DataKd:  0.650nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495240(CHEMBL3104278)
Affinity DataKd:  0.660nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495256(CHEMBL3104285)
Affinity DataKd:  0.660nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50401335(CHEMBL2205798)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50362222(CHEMBL1939384)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50568576(CHEMBL4873718)
Affinity DataIC50: 0.710nMAssay Description:Inhibition of recombinant human N terminal his-tagged HSP90 alpha (1 to 732 residues) expressed in Escherichia coli measured after 60 mins by Floures...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50593503(CHEMBL5174695)
Affinity DataKd:  0.710nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50276167(Carbamic acid (4E,10E)-(8S,9S,12S,13R,14S,16R)-13,...)
Affinity DataKd:  0.800nMAssay Description:Binding affinity to human recombinant Hsp90alpha N-terminal domain by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152274(US8993556, 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phen...)
Affinity DataKd:  0.800nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM152278(US8993556, N-[1-(4,4-Difluorocyclohexyl)piperidin-...)
Affinity DataKd:  0.800nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50362221(CHEMBL1939385)
Affinity DataKd:  0.800nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50495239(CHEMBL3104272)
Affinity DataKd:  0.820nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50645077(CHEMBL5569309)
Affinity DataKd:  0.990nMAssay Description:Binding affinity to human N-terminal his tagged Hsp90alpha (1 to 241 residues) expressed in Escherichia coli (DE3) strain assessed as dissociation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50401336(CHEMBL2205245)
Affinity DataIC50: 1nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 1nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandPNGBDBM50394053(CHEMBL2158562)
Affinity DataKi: <1nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
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