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TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417006(CHEMBL1256414)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM22867(3,3-diethyl-1-[(4R,7R)-6-methyl-6,11-diazatetracyc...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417010(CHEMBL1255723)
Affinity DataKi:  0.182nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417019(CHEMBL1256378)
Affinity DataKi:  0.204nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50213212(CHEMBL50390)
Affinity DataKi:  0.25nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM85709(S18616)
Affinity DataKi:  0.251nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417009(CHEMBL1255724)
Affinity DataKi:  0.347nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  0.370nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50017519(CHEMBL73151 | Terguride | 1,1-Diethyl-3-(7-methyl-...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM84994(NSC_163091 | CAS_163091 | ORG-5222)
Affinity DataKi:  0.490nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataKi:  0.5nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50090256(ascorbic acid | (R)-5-((S)-1,2-dihydroxyethyl)-3,4...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM69602(WB-4101 hydrochloride | N-(2,3-dihydro-1,4-benzodi...)
Affinity DataKd:  0.631nMAssay Description:Binding affinity to alpha-adrenergic receptor (unknown origin) in central nervous systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417020(CHEMBL1256609)
Affinity DataKi:  0.692nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50562355(CHEMBL4755913)
Affinity DataKi:  0.820nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in human brain membrane by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM81811(MK-912 | NSC_123679 | CAS_123679 | L-657,743)
Affinity DataKi:  0.890nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
LigandPNGBDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417008(CHEMBL1255771)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50403738(CHEMBL351483)
Affinity DataIC50: 0.955nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417018(CHEMBL1255770)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  1.18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2011
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details
PubMed
LigandPNGBDBM50052882(AGN-193080 | Imidazolidin-2-ylidene-(5-methyl-3,4-...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM85595(CAS_105182-45-4 | NSC_72036 | Fluparoxan)
Affinity DataKi:  1.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50052880(Imidazolidin-2-ylidene-(5-methyl-quinoxalin-6-yl)-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details

TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50403740(CHEMBL165350)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50052880(Imidazolidin-2-ylidene-(5-methyl-quinoxalin-6-yl)-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50403739(CHEMBL163247)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]RX821002 from alpha-2 adrenergic receptor in human brain pre-frontal cortex neural membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to alpha2 adrenoceptor in human cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50403755(CHEMBL163190)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
LigandPNGBDBM50021809((2,6-Dichloro-4-iodo-phenyl)-imidazolidin-2-yliden...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2018
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50146518(R-226161 | cis-(+/-)-7,8-dimethoxy-3-[4-(2-methyl-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]rawolscine from human cloned adrenergic alpha-2B receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50403752(CHEMBL162370)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.57nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2012
Entry Details
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417013(CHEMBL1256610)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50476638(CHEMBL75389)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandPNGBDBM50476638(CHEMBL75389)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in human brain membrane by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  1.62nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50403747(CHEMBL162826)
Affinity DataIC50: 1.70nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50020192(8-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-1-phen...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50562354(CHEMBL4763113)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in human brain membrane by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50403746(CHEMBL162147)
Affinity DataIC50: 1.90nMAssay Description:Binding affinity at human Alpha-2B adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Pierre Fabre Research Center

Curated by ChEMBL
LigandPNGBDBM50417011(CHEMBL1255617)
Affinity DataKi:  1.91nMAssay Description:Displacement of [3H]-RX821002 from human adrenergic alpha2B receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
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