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Report error Found 137 for UniProtKB: P21447
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50095341(3,5,7-Trihydroxy-2-(4-octyl-phenyl)-chromen-4-one ...)
Affinity DataKd:  57nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50084981(8-((E)-3,7-Dimethyl-octa-2,6-dienyl)-3,5,7-trihydr...)
Affinity DataKd:  120nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50084975(6-((E)-3,7-Dimethyl-octa-2,6-dienyl)-3,5,7-trihydr...)
Affinity DataKd:  180nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50127138(Oriconazole | Sporanox (TN) | 2-(butan-2-yl)-4-{4-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140839(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 236nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50084977(3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxy-phenyl)...)
Affinity DataKd:  250nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50249649(Dimethyl-(8-phenyl-2,3,5,6-tetrahydro-1H,4H-13-sel...)
Affinity DataIC50: 280nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140852(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 294nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140844(8-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 356nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50084976(3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxy-phenyl)...)
Affinity DataKd:  370nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140845(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 443nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140857(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 608nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140834(9-Carbamoyl-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-p...)
Affinity DataIC50: 651nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140866(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 731nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140847(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 780nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140877((4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-...)
Affinity DataIC50: 780nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140846(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 850nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140872(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 950nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140868(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140864(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140856(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140838(9-Chloro-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140836(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140870((4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50095339(3,5,7-Trihydroxy-2-(4-iodo-phenyl)-chromen-4-one |...)
Affinity DataKd:  1.06E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140862(5-Benzyl-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140875(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140880(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140859(9-Chloro-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM24226(cid_2247 | [3H]-ASTEMIZOLE | Hismanal | ASTEMIZOLE...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140840((4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140863(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140837(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140861(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140853((4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140854(8-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50095338(2-(4-Benzhydryl-phenyl)-3,5,7-trihydroxy-chromen-4...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140867(9-Chloro-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140848(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM18957((2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-di...)
Affinity DataKi:  2.10E+3nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50084979(Dehydrosilylbin | 3,5,7-Trihydroxy-2-[3-(4-hydroxy...)
Affinity DataKd:  2.20E+3nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50366785(NELFINAVIR)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140850(9-Chloro-4-{4-[2-(3,4-difluoro-phenyl)-ethyl]-pipe...)
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50367298(Cardene | NICARDIPINE)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140860(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 3.31E+3nMAssay Description:In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50140842(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKi:  3.65E+3nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50095342(2-(2,4-Dichloro-phenyl)-3,5,7-trihydroxy-chromen-4...)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50017712(Apoplon | 3,4,5-trimethoxybenzoyl methyl reserpate...)
Affinity DataKi:  4.03E+3nMAssay Description:TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataKd:  4.50E+3nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
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