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Report error Found 2523 for UniProtKB: P23944
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50036910(4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | CHEMBL3...)
Affinity DataEC50:  153nMAssay Description:50% Molar effective concentration for agonistic activity against Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50036913(4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole | med...)
Affinity DataEC50:  281nMAssay Description:50% Molar effective concentration afainst Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50470944(CHEMBL336161)
Affinity DataEC50:  1.02E+3nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataEC50:  12nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM30712(SMR000059324 | Oxymetazoline | cid_66259 | 6-tert-...)
Affinity DataEC50:  8.32E+3nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,...)
Affinity DataEC50:  2.57E+3nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50470943(CHEMBL133451)
Affinity DataEC50: <1.00E+5nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50067212(CHEBI:8093 | Cyclomydril | Duo-Medihaler | Phenyle...)
Affinity DataEC50:  155nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022722((1R, 2S)-2-Amino-1-phenyl-propan-1-ol | CHEMBL1365...)
Affinity DataEC50:  7.59E+4nMAssay Description:Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,...)
Affinity DataEC50:  2.57E+3nMAssay Description:Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118702(CHEMBL1076 | Orvaten | 2-Amino-1-(2,5-dimethoxy-ph...)
Affinity DataEC50:  1.86E+3nMAssay Description:Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50497037(CHEMBL3248387)
Affinity DataKd:  141nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497038(CHEMBL3248388)
Affinity DataKd:  562nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497039(CHEMBL3248383)
Affinity DataKd:  617nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497040(CHEMBL3248386)
Affinity DataKd:  1.02E+3nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50497041(CHEMBL3248385)
Affinity DataKd:  309nMAssay Description:Displacement of [3H]dihydroazapetine from alpha-adrenoreceptor in rat vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM35234(Noradrenaline,(+) | NOREPINEPHRINE | DL-[7-3H]nore...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50042998(5-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-d...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50042998(5-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-d...)
Affinity DataEC50:  1.50E+4nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataEC50:  3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM35234(Noradrenaline,(+) | NOREPINEPHRINE | DL-[7-3H]nore...)
Affinity DataEC50:  3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50019060(CHEMBL287587 | 4-(2-Amino-1-hydroxy-ethyl)-3-fluor...)
Affinity DataEC50: >1.00E+5nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118702(CHEMBL1076 | Orvaten | 2-Amino-1-(2,5-dimethoxy-ph...)
Affinity DataEC50:  1.90E+3nMAssay Description:Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,...)
Affinity DataEC50:  2.60E+3nMAssay Description:Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022722((1R, 2S)-2-Amino-1-phenyl-propan-1-ol | CHEMBL1365...)
Affinity DataEC50:  5.80E+4nMAssay Description:Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183662(4-(4-chlorobenzyl)-2-(4-nitrophenyl)phthalazin-1(2...)
Affinity DataEC50:  2.90E+4nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183663(4-(4-chlorobenzyl)-2-tert-butylphthalazin-1(2H)-on...)
Affinity DataEC50: >1.00E+5nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM56339(SMR000113649 | MLS000547504 | CHEMBL63976 | cid_10...)
Affinity DataEC50:  790nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183664(4-(4-(methylthio)benzyl)-2-allylphthalazin-1(2H)-o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183665(4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one | C...)
Affinity DataEC50:  2.60E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131408(4-(3,4-Dimethoxy-benzyl)-2-methyl-2H-phthalazin-1-...)
Affinity DataEC50:  2.20E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183666(4-(2,4-dichlorobenzyl)-2-methylphthalazin-1(2H)-on...)
Affinity DataEC50:  1.20E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183667(4-(3,4-dimethoxybenzyl)-2-ethylphthalazin-1(2H)-on...)
Affinity DataEC50:  5.30E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183668(4-(4-chlorobenzyl)-2-phenylphthalazin-1(2H)-one | ...)
Affinity DataEC50: >1.00E+5nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183669(4-(4-(methylthio)benzyl)-2-methylphthalazin-1(2H)-...)
Affinity DataEC50:  930nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131402(4-Benzo[1,3]dioxol-5-ylmethyl-2-methyl-2H-phthalaz...)
Affinity DataEC50:  930nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183670(4-(3,4-dimethoxybenzyl)-2-(4-nitrophenyl)phthalazi...)
Affinity DataEC50: >1.00E+5nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131404(4-(4-methoxybenzyl)phthalazin-1(2H)-one | 4-(4-Met...)
Affinity DataEC50: >1.00E+4nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131411(4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one | ...)
Affinity DataEC50:  430nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183673(4-(4-(methylthio)benzyl)-2-phenylphthalazin-1(2H)-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183674(4-(4-(methylthio)benzyl)-2-butylphthalazin-1(2H)-o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131420(4-(3,4,5-trimethoxybenzyl)phthalazin-1(2H)-one | 4...)
Affinity DataEC50: >1.00E+5nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183671(4-(4-(methylthio)benzyl)-2-ethylphthalazin-1(2H)-o...)
Affinity DataEC50: >1.00E+5nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183675(4-(4-(methylthio)benzyl)phthalazin-1(2H)-one | CHE...)
Affinity DataEC50:  5.50E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183678(4-(2-chlorobenzyl)phthalazin-1(2H)-one | CHEMBL378...)
Affinity DataEC50:  1.90E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183679(4-(3,4-dimethoxybenzyl)-2-allylphthalazin-1(2H)-on...)
Affinity DataEC50:  9.80E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183676(4-(3,4-dimethoxybenzyl)-2-tert-butylphthalazin-1(2...)
Affinity DataEC50:  1.00E+4nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183677(4-(3,4-dimethoxybenzyl)-2-butylphthalazin-1(2H)-on...)
Affinity DataEC50:  5.40E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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