Compile Data Set for Download or QSAR
Report error Found 1015 for UniProtKB: P31422
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094843((-)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Affinity DataEC50:  2.07nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50332968(7-ethoxy-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151453((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-difluoro-benzyloxy...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataKi:  3.04nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094843((-)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Affinity DataKi:  3.62nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151438((1R,2R,3R,5R,6R)-2-Amino-3-benzhydryloxy-6-fluoro-...)
Affinity DataKi:  3.93nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279772(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Affinity DataKi:  4.11nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  4.46nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151447((1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-benzyloxy)-6-...)
Affinity DataKi:  4.77nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151473((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-2-...)
Affinity DataKi:  5.43nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50332972(7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50:  9.80nMAssay Description:Agonist activity at mGlu2/3 receptor in Sprague-Dawley rat forebrain assessed as inhibition of spontaneous Ca2+ oscillations in cortical neurons afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50138784((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Affinity DataEC50:  11nMAssay Description:Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50138784((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Affinity DataEC50:  11nMAssay Description:Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50332970(7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 14.2nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151446((1R,2R,3R,5R,6R)-2-Amino-3-benzyloxy-6-fluoro-bicy...)
Affinity DataKi:  15.9nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 16nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant mGluR3 receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 16nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50333000(4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromet...)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50376468(CHEMBL259054)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataIC50: 24nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50072177((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 29nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50332989(4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50332966(7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at rat mGluR3 receptor expressed in CHO cells assessed as inhibition of GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50376467(CHEMBL260636)
Affinity DataIC50: 33nMAssay Description:Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50138781(2-(Amino-carboxy-methyl)-3-methyl-cyclopropanecarb...)
Affinity DataEC50:  38nMAssay Description:Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50397661(EGLUMEGAD)
Affinity DataEC50:  38nMAssay Description:Agonist activity at mGLUR3 in rat cerebral cortex assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM393885(US9969726, Example 182 | US10597367, Example 182)
Affinity DataEC50:  40nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50072170((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 40nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094842((+/-)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-di...)
Affinity DataKi:  41.7nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50332991(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataEC50:  45.4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM393885(US9969726, Example 182 | US10597367, Example 182)
Affinity DataEC50:  50nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataKi:  53.5nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  58nMAssay Description:Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  60nMAssay Description:Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM393849(US9969726, Example 137 | US10597367, Example 137)
Affinity DataEC50:  60nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50:  62.8nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094841(2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarbox...)
Affinity DataKi:  65.9nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017610(CHEMBL3288662)
Affinity DataIC50: 67nMAssay Description:Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151444((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-hydroxy-bicycl...)
Affinity DataKi:  67.1nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM393886(US9969726, Example 183 | US10597367, Example 183)
Affinity DataEC50:  70nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent

TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50107108((1S,2S,3R)-2-(Amino-carboxy-methyl)-3-[2-(9H-xanth...)
Affinity DataIC50: 75nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant Metabotropic glutamate receptor 3 expressed in HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50072172((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50: 76nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017663(CHEMBL3288676)
Affinity DataIC50: 78nMAssay Description:Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017663(CHEMBL3288676)
Affinity DataIC50: 78nMAssay Description:Inhibition of rat mGlu3 receptor transfected in HEK293 cells coexpressing mouse Galpha15 assessed as decrease in glutamate-induced calcium signaling ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50576811(CHEMBL4863303)
Affinity DataEC50:  79nMAssay Description:Positive allosteric modulator activity at rat mGlu3 receptor transfected in GIRK channel overexpressing cells assessed as potentiation of glutamate-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM393834(US9969726, Example 122 | US10597367, Example 122)
Affinity DataEC50:  80nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent

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