Compile Data Set for Download or QSAR
Report error Found 36 of affinity data for UniProtKB/TrEMBL: P34981
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196446BDBM50196446([N tau(1)-Me-His]-TRH | CHEMBL224730)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50072394BDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196451BDBM50196451((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196451BDBM50196451((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196446BDBM50196446([N tau(1)-Me-His]-TRH | CHEMBL224730)
Affinity DataEC50:  5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196457BDBM50196457((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196457BDBM50196457((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50072394BDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196445BDBM50196445((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataEC50:  380nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196445BDBM50196445((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataKi:  400nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196449BDBM50196449((2S)-1-{(2S)-3-(1-allyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataEC50:  5.10E+3nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196449BDBM50196449((2S)-1-{(2S)-3-(1-allyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataKi:  7.50E+3nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196458BDBM50196458((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataEC50:  1.70E+4nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196452BDBM50196452((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196452BDBM50196452((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196459BDBM50196459((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196450BDBM50196450((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196450BDBM50196450((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196454BDBM50196454((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196460BDBM50196460((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196456BDBM50196456((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196459BDBM50196459((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196461BDBM50196461((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196453BDBM50196453((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196455BDBM50196455((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196448BDBM50196448((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196448BDBM50196448((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196453BDBM50196453((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196454BDBM50196454((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196447BDBM50196447((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196456BDBM50196456((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196447BDBM50196447((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196458BDBM50196458((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196461BDBM50196461((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196455BDBM50196455((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196460BDBM50196460((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed