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TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205961BDBM50205961(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205952BDBM50205952(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205910BDBM50205910(methyl (3S)-3-{2-[(1,3-benzodioxol-5-ylmethyl)amin...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205937BDBM50205937(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205950BDBM50205950(2-((R)-1-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)pyrro...)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205947BDBM50205947(N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZO...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111438BDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205911BDBM50205911(2-((R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205932BDBM50205932(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205956BDBM50205956(N-(1,3-benzodioxol-5-ylmethyl)-1-[6-chloro-2-(1H-i...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205954BDBM50205954(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205957BDBM50205957(N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205905BDBM50205905(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205926BDBM50205926(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205907BDBM50205907((2R)-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-1-(6-et...)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205973BDBM50205973(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205938BDBM50205938(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111438BDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataIC50: 0.600nMAssay Description:Inhibitory activity against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205909BDBM50205909(N-(1,3-benzodioxol-5-ylmethyl)-4-(2-furanylcarbony...)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205968BDBM50205968(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205930BDBM50205930(2-((R)-4-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205904BDBM50205904(1-[2-(1H-imidazol-1-yl)-4-pyrimidinyl]-N-[(4-metho...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205971BDBM50205971(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205964BDBM50205964(N-(1,3-benzodioxol-5-ylmethyl)-1-[2-(1H-imidazol-y...)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205965BDBM50205965(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205931BDBM50205931(N-(1,3-benzodioxol-5-ylmethyl)-1-[2-(1H-imidazol-y...)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205929BDBM50205929(4-(acetyl)-N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205924BDBM50205924(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205974BDBM50205974(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205920BDBM50205920(N-[(1,3-benzodioxol-5-yl)methyl]-1-[2-(1H-imidazol...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205921BDBM50205921(3-[2-[(1,3-benzodioxol-5-ylmethyl)amino]-2-oxoethy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111448BDBM50111448(N-Benzo[1,3]dioxol-5-ylmethyl-2-[1-(6-chloro-2-imi...)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205976BDBM50205976(N-[(1,3-benzodioxol-5-yl)methyl]-4-[(5-dimethylami...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205953BDBM50205953(3-[2-[(1,3-benzodioxol-5-ylmethyl)amino]-2-oxoethy...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205903BDBM50205903(1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-[(3,4-dim...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230993BDBM50230993(CHEMBL256147 | 2-Amino-5-(N'-methyl-guanidino)-pen...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant iNOS assessed as conversion of [3H]L-arginine to [3H]L-citrulline preincubated for 15 mins measured after 45 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386178BDBM50386178(ONO-1714 | CHEMBL1800346)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386178BDBM50386178(ONO-1714 | CHEMBL1800346)
Affinity DataKi:  1.86nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205955BDBM50205955(N-[(1,3-benzodioxol-5-yl)methyl]-4-[2-(1H-imidazol...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138191BDBM50138191(ONO-1714 | (1S,5S,6R,7R)-7-Chloro-5-methyl-2-aza-b...)
Affinity DataKi:  2nMAssay Description:Inhibition of human iNOS overexpressed in baculovirus infected Sf21 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50124519BDBM50124519(5,8-Difluoro-2-furan-2-yl-1,2-dihydro-quinazolin-4...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity of compound against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 331831BDBM331831(US10189791, CDDO-Im 1)
Affinity DataIC50: 2nMAssay Description:Because oxidative and inflammatory stress contribute to carcinogenesis (Albini & Sporn (2007) Nature Rev. Cancer 7:139-147), it was determined whethe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205980BDBM50205980(N-[(1,3-benzodioxol-5-yl)methyl]hexahydro-1-[2-(1H...)
Affinity DataIC50: 2nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111438BDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataKi:  2.20nMAssay Description:Binding against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205914BDBM50205914(N-(1,3-benzodioxol-5-ylmethyl)-1-[2-(1H-imidazol-y...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205944BDBM50205944(N-[(4-fluorophenyl)methyl]-1-[2-(1H-imidazol-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205940BDBM50205940(1-[2-(1H-imidazol-1-yl)-4-pyrimidinyl]-N-[2-(4-met...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205970BDBM50205970(1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-[(3-metho...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339997BDBM50339997((R)-2-(3-amino-1-phenylpropoxy)-4-chlorobenzonitri...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Berlex Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50356475BDBM50356475(CHEMBL1911984)
Affinity DataEC50:  4nMAssay Description:Inhibition of human iNOS expressed in human HEK293 cells assessed as nitrite accumulation after 18 hrs by 2,3-diaminonapthalene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
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