Compile Data Set for Download or QSAR
Report error Found 247 of affinity data for UniProtKB/TrEMBL: P37268
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292336BDBM50292336(desacetoxy-zaragozic acid | CHEMBL507677)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038096BDBM50038096((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.240nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038102BDBM50038102((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.280nMAssay Description:compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292333BDBM50292333(zaragozic acid C | CHEMBL505374)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038089BDBM50038089((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.300nMAssay Description:compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338903BDBM50338903(Ethyl 1-{4-[{4-chloro-2-[(2-fluorophenyl)(hydroxy)...)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285068BDBM50285068((S)-2-{[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50: 0.520nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285068BDBM50285068((S)-2-{[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50: 0.520nMAssay Description:Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038093BDBM50038093((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.640nMAssay Description:compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50403481BDBM50403481(CHEMBL2115091)
Affinity DataIC50: 0.730nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338880BDBM50338880(Ethyl 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038106BDBM50038106((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.960nMAssay Description:Compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292846BDBM50292846(4-(4-Biphenyl)butyldiphosphonic Acid Tetrapotassiu...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338910BDBM50338910(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338907BDBM50338907(Ethyl 1-{4-[{4-chloro-2-[hydroxy(2-methoxyphenyl)-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338892BDBM50338892(Benzyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285065BDBM50285065((S)-2-{[(1S,2S)-2-Biphenyl-4-yl-3-(3,4-dichloro-ph...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338934BDBM50338934(1-{4-[{4-Chloro-2-[hydroxy(2-methoxyphenyl)methyl]...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338919BDBM50338919(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338883BDBM50338883(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50208574BDBM50208574((R)-3-(2-(2-benzyl-6-((3R,4S)-3-hydroxy-4-methoxyp...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338887BDBM50338887(N-Butyl-1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydrox...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338925BDBM50338925(1-{4-[{4-Chloro-2-[hydroxy(2-methoxyphenyl)methyl]...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292334BDBM50292334(zaragozic acid F | CHEMBL445291)
Affinity DataIC50: 2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281106BDBM50281106((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338937BDBM50338937(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50: 2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338905BDBM50338905(Ethyl 1-{4-[{4-chloro-2-[(2-chloro-4-fluorophenyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292852BDBM50292852(1-Phosphono-4-[3-(benzofuran-5-yloxy)phenyl]butyls...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338891BDBM50338891(Ethyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338885BDBM50338885(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50288819BDBM50288819((R)-4-[(E)-(1S,2S)-2-(3,4-Dichloro-benzyl)-1-methy...)
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338916BDBM50338916(Ethyl 1-{4-[{4-chloro-2-[hydroxy(2-methoxyphenyl)-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338928BDBM50338928(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049215BDBM50049215(Tripotassium salt of4-[3-(2-Benzyl-phenoxy)-phenyl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292847BDBM50292847(4-[4-(4-Trifluoromethylphenyl)phenyl)]butyldiphosp...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50285069BDBM50285069((S)-2-{[(1S,2S)-2-Biphenyl-4-yl-3-(4-chloro-phenyl...)
Affinity DataIC50: 3.20nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50038097BDBM50038097((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 3.20nMAssay Description:compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338886BDBM50338886(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50288818BDBM50288818((R)-4-[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluoro...)
Affinity DataIC50: 3.90nMAssay Description:Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50281101BDBM50281101((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292849BDBM50292849(1-Phosphono-4-[3-(4-fluorophenoxy)-6-fluoro-phenyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292335BDBM50292335(zaragozic acid E | CHEMBL508773)
Affinity DataIC50: 4nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051873BDBM50051873((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity of compound was measured against Candida squalene synthase(SQS) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article
PDB3D3D Structure (crystal)
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051873BDBM50051873((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Candida albicans squalene synthase(SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50283080BDBM50283080((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against Candida albicans squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50037286BDBM50037286((1S,3S,4S,5R,6R,7R)-1-((4R,5S)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 5nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50292863BDBM50292863(1-Phosphono-4-[3-(2-fluorophenoxy)phenyl]butylsulf...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50208577BDBM50208577((R)-3-(2-(2-benzyl-6-(3-methoxypropoxy)pyridin-3-y...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338877BDBM50338877(1-{4-[{4-Chloro-2-[2,3-dihydro-1,4-benzodioxin-5-y...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338929BDBM50338929(1-{4-[{4-Chloro-2-[2,3-dihydro-1,4-benzodioxin-5-y...)
Affinity DataIC50: 7nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
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