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Report error Found 1113 of affinity data for UniProtKB/TrEMBL: P39900
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360964BDBM50360964(CHEMBL1935285)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360965BDBM50360965(CHEMBL1935286)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265078BDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50592891BDBM50592891(CHEMBL5191016)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human MMP-12 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 92441BDBM92441(RXP470, Compound 4 | RXP470, 1)
Affinity DataKi:  0.190nM ΔG°:  -55.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299051BDBM50299051(N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfon...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360967BDBM50360967(CHEMBL1935288)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 92441BDBM92441(RXP470, Compound 4 | RXP470, 1)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50161330BDBM50161330((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360966BDBM50360966(CHEMBL1935287)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50148216BDBM50148216(4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265078BDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.240nMpH: 6.8Assay Description:Inhibition of human MMP12 catalytic domain (98 to 266) at pH 6.8 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505154BDBM50505154(CHEMBL4581500)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50265078BDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426080BDBM50426080(CHEMBL2316257)
Affinity DataKi:  0.280nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426080BDBM50426080(CHEMBL2316257)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360956BDBM50360956(CHEMBL1935304)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 120258BDBM120258(US8691753, 95 bis)
Affinity DataKi:  0.300nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50610465BDBM50610465(CHEMBL5288452)
Affinity DataIC50: 0.368nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50295489BDBM50295489((S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]thiophe...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360968BDBM50360968(CHEMBL1935290)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360963BDBM50360963(CHEMBL1935284)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50062351BDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50610466BDBM50610466(CHEMBL5280430)
Affinity DataIC50: 0.566nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360959BDBM50360959(CHEMBL1935280)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299051BDBM50299051(N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfon...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 1 hr preincubation by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50299051BDBM50299051(N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfon...)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 30 mins preincubation by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28480BDBM28480((2S)-3-methyl-2-({12-[(thiophen-3-ylcarbamoyl)amin...)
Affinity DataIC50: 0.900nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505152BDBM50505152(CHEMBL4435285)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50428828BDBM50428828(CHEMBL2337131)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50151732BDBM50151732(4-[4-(2,4-Dichloro-benzyloxy)-benzenesulfonyl]-3-h...)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of matrix metalloprotease 12More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50026624BDBM50026624(CHEMBL1935289)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505151BDBM50505151(CHEMBL4520279)
Affinity DataKi:  1nMAssay Description:Inhibition of human MMP12 by photoaffinity probe based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50360969BDBM50360969(CHEMBL1935291)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605508BDBM605508(US11673884, Compound AC-2)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605513BDBM605513(US11673884, Compound AC-6)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50168737BDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MMP12 using Mca-PQGL-(3-[2, 4-dinitrophenyl]-L-2, 3-diaminopropionyl)-AR-OH as substrate after 2 to 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605512BDBM605512(US11673884, Compound AC-5)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50434226BDBM50434226(CHEMBL2385483)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605509BDBM605509(US11673884, Compound AC-3)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605517BDBM605517(US11673884, Compound AC-10)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605516BDBM605516(US11673884, Compound AC-9)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605515BDBM605515(US11673884, Compound AC-8)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50062351BDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50555050BDBM50555050(CHEMBL4764575)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605519BDBM605519(US11673884, Compound AC-12)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 605518BDBM605518(US11673884, Compound AC-11)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 120222BDBM120222(US8691753, 71)
Affinity DataKi:  1.05nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details
US Patent

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28481BDBM28481((2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]car...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50555052BDBM50555052(CHEMBL4751015)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
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