Affinity DataIC50: 1.5nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia c...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Uncompetitive binding affinity to microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expres...More data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Uncompetitive binding affinity to C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) assessed...More data for this Ligand-Target Pair
Affinity DataKi: 3.20nMAssay Description:Binding affinity to wild-type human CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia c...More data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Binding affinity to wild-type human CENP-E assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Uncompetitive-like binding affinity to C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) ass...More data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Uncompetitive binding affinity to microtubule-stimulated ATPase activity of C-terminal 6-his-tagged CENP-E (2 to 340 residues)(unknown origin) expres...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity to human CENP-E K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity to human CENP-E T183A mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity to human CENP-E I182L mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of CENP-E in human SW48 cells assessed as decrease in cell viability after 72 hrs by Cell-titer Glo reagent assayMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Binding affinity to human CENP-E I182L/K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of CENP-E in human SW620 cells expressing KRAS mutant assessed as decrease in cell viability after 72 hrs by Cell-titer Glo reagent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of CENP-E in human HCT-116 cells expressing KRAS mutant assessed as decrease in cell viability after 72 hrs by Cell-titer Glo reagent assa...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of CENP-E in human RKO cells expressing BRAF mutant assessed as decrease in cell viability after 72 hrs by Cell-titer Glo reagent assayMore data for this Ligand-Target Pair
Affinity DataKi: 61nMAssay Description:Binding affinity to human CENP-E I182L/T183A mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Binding affinity to human CENP-E I182L/T183A/K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 73nMAssay Description:Binding affinity to human CENP-E I182L/T183A/K184T mutant assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 134nMAssay Description:Inhibition of CENP-E in human SK-N-FI cells assessed as decrease in cell viability after 72 hrs in presence of ERK1 siRNA by Cell-titer Glo reagent a...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 283nMAssay Description:Inhibition of CENP-E in human SK-N-FI cells assessed as decrease in cell viability after 72 hrs by Cell-titer Glo reagent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Inhibition of human ATPase activity of CENP-E motor domain assessed as ADP production after 60 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
