Compile Data Set for Download or QSAR
Report error Found 1067 for UniProtKB: Q05769
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50: 0.00603nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272129(4-(5-methyl-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272125(4-(3-p-tolyl-1H-indol-2-yl)benzenesulfonamide | CH...)
Affinity DataIC50: 0.0692nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272105(4-(3-phenyl-1H-indol-2-yl)benzenesulfonamide | CHE...)
Affinity DataIC50: 0.0891nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272126(2-(4-(methylsulfonyl)phenyl)-3-p-tolyl-1H-indole |...)
Affinity DataIC50: 0.0891nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272110(4-(5-chloro-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 0.141nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272097(3-(3,4-dimethylphenyl)-2-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272128(N-(4-(3-phenyl-1H-indol-2-yl)phenylsulfonyl)acetam...)
Affinity DataIC50: 0.178nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272130(5-methyl-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-...)
Affinity DataIC50: 0.282nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272111(5-chloro-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-...)
Affinity DataIC50: 0.363nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272124(3-(4-bromophenyl)-2-(4-(methylsulfonyl)phenyl)-1H-...)
Affinity DataIC50: 0.372nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of LPS-induced COX2 activity in C57BL/6J mouse peritoneal macrophages by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50272090(4-(5-chloro-3-(4-chlorophenyl)-1H-indol-2-yl)benze...)
Affinity DataIC50: 0.537nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50: 0.601nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50272106(2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-indole | ...)
Affinity DataIC50: 0.603nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50094542(1,3-diphenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrol...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094542(1,3-diphenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrol...)
Affinity DataIC50: 0.701nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50272092(5-chloro-3-(3-chlorophenyl)-2-(4-(methylsulfonyl)p...)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50094539(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50094539(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataIC50: 1.30nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50272113(5-bromo-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-i...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50272127(4-(3-(3,4-dimethylphenyl)-1H-indol-2-yl)benzenesul...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50094540(1,3-diphenyl-4,5,6,7-tetrahydro-2H-isoindole | CHE...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50094540(1,3-diphenyl-4,5,6,7-tetrahydro-2H-isoindole | CHE...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094546(3,5-Diphenyl-4-aza-tricyclo[5.2.2.0*2,6*]undeca-2,...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094546(3,5-Diphenyl-4-aza-tricyclo[5.2.2.0*2,6*]undeca-2,...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50094563(1,3-dip-tolyl-4,5,6,7-tetrahydro-2H-isoindole | 1,...)
Affinity DataIC50: 1.67nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094534(1,3-Bis-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094534(1,3-Bis-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50094532(1,3-Diphenyl-4,5,6,7-tetrahydro-isoindol-2-ylamine...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094532(1,3-Diphenyl-4,5,6,7-tetrahydro-isoindol-2-ylamine...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataIC50: 1.90nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
LigandPNGBDBM50029593(CHEMBL7162 | NS398 | NS-398 | N-(2-Cyclohexyloxy-4...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against murine Prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50272109(4-(5-fluoro-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50: 2nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50173290(4-[5-(2-Fluoro-ethyl)-3-phenyl-isoxazol-4-yl]-benz...)
Affinity DataIC50: 2nMAssay Description:Tested for prostaglandin E2 production as a function of COX-2 inhibition using endotoxin-treated murine RAW 264.7 macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50173289(2-Fluoro-4-(5-methyl-3-phenyl-isoxazol-4-yl)-benze...)
Affinity DataIC50: 2nMAssay Description:Tested for prostaglandin E2 production as a function of COX-2 inhibition using endotoxin-treated murine RAW 264.7 macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50173288(4-(5-Fluoromethyl-3-phenyl-isoxazol-4-yl)-benzenes...)
Affinity DataIC50: 2nMAssay Description:Tested for prostaglandin E2 production as a function of COX-2 inhibition using endotoxin-treated murine RAW 264.7 macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50173287(4-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-yl]-ben...)
Affinity DataIC50: 2nMAssay Description:Tested for prostaglandin E2 production as a function of COX-2 inhibition using endotoxin-treated murine RAW 264.7 macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50492037(CHEMBL2391055)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50361590(CHEMBL1939677)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50094558(3,5-Diphenyl-4-aza-tricyclo[5.2.1.0*2,6*]deca-2,5-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50094558(3,5-Diphenyl-4-aza-tricyclo[5.2.1.0*2,6*]deca-2,5-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094548(1,3-Bis-(4-fluoro-phenyl)-2,4,5,6-tetrahydro-cyclo...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50094548(1,3-Bis-(4-fluoro-phenyl)-2,4,5,6-tetrahydro-cyclo...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
LigandPNGBDBM50589579(CHEMBL5185981)
Affinity DataIC50: 3nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production and measured after 24 hrs by enzyme immuno-assay (EIA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM50094528(5,6-Dimethyl-1,3-diphenyl-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 1067 total ) | Next | Last >>
Jump to: