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Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50373177(CHEMBL404038)
Affinity DataKd:  0.0400nMAssay Description:Binding affinity to human recombinant RNase LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085558(Oligoadenylate analogue | CHEMBL402676)
Affinity DataEC50:  0.130nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085554(Oligoadenylate analogue | 5'-O-MONOPHOSPHORYLADENY...)
Affinity DataEC50:  0.150nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085558(Oligoadenylate analogue | CHEMBL402676)
Affinity DataEC50:  0.200nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085554(Oligoadenylate analogue | 5'-O-MONOPHOSPHORYLADENY...)
Affinity DataEC50:  0.200nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataEC50:  0.210nMAssay Description:Binding affinity of compound to human recombinant Ribonuclease L was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50373177(CHEMBL404038)
Affinity DataKd:  0.220nMAssay Description:Displacement of 5'-phosphorylated, 2',5'-oligoadenylate from human recombinant RNase L assessed as decrease in resonance by surface plasma resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085553(Oligoadenylate analogue | CHEMBL214603)
Affinity DataEC50:  0.240nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085553(Oligoadenylate analogue | CHEMBL214603)
Affinity DataEC50:  0.300nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50183267(CHEMBL3817920)
Affinity DataEC50:  0.450nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50373177(CHEMBL404038)
Affinity DataEC50:  0.5nMAssay Description:Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085556(Oligoadenylate analogue | CHEMBL405496)
Affinity DataEC50:  0.680nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085555(Oligoadenylate analogue | CHEMBL384725)
Affinity DataEC50:  0.700nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085553(Oligoadenylate analogue | CHEMBL214603)
Affinity DataIC50: 0.720nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085556(Oligoadenylate analogue | CHEMBL405496)
Affinity DataEC50:  0.800nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085555(Oligoadenylate analogue | CHEMBL384725)
Affinity DataEC50:  0.840nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50309129({[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)-4-[({[(2R,3S,4...)
Affinity DataEC50:  2.30nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50183270(CHEMBL3818262)
Affinity DataEC50:  2.40nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50309129({[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)-4-[({[(2R,3S,4...)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50309130({[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)-4-[({[(2R,3R,4...)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085558(Oligoadenylate analogue | CHEMBL402676)
Affinity DataIC50: 2.60nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50183271(CHEMBL3819183)
Affinity DataEC50:  2.70nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085559(Oligoadenylate analogue | CHEMBL410213)
Affinity DataEC50:  4nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50388146(CHEMBL2058766)
Affinity DataEC50:  4.20nMAssay Description:Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085559(Oligoadenylate analogue | CHEMBL410213)
Affinity DataEC50:  4.60nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50438548(CHEMBL2414867)
Affinity DataEC50:  6.10nMAssay Description:Activation of human recombinant RNase L endonuclease activity using 6-FAM-UUA UCA AAU UCU UAU UUG CCC CAU UUU UUU GGU UUA-BHQ-1 as substrate assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50388147(CHEMBL2058765)
Affinity DataEC50:  6.5nMAssay Description:Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085554(Oligoadenylate analogue | 5'-O-MONOPHOSPHORYLADENY...)
Affinity DataIC50: 7.30nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50152834([(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-[({[(2R...)
Affinity DataEC50:  9.70nMAssay Description:Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50183322(CHEMBL601940)
Affinity DataEC50:  13nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50: 13nMAssay Description:Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50388148(CHEMBL2058764)
Affinity DataEC50:  15nMAssay Description:Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085557(Oligoadenylate analogue | CHEMBL407239)
Affinity DataEC50:  16nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50152834([(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-[({[(2R...)
Affinity DataEC50:  17nMAssay Description:Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50438547(CHEMBL2414866)
Affinity DataEC50:  19nMAssay Description:Activation of human recombinant RNase L endonuclease activity using 6-FAM-UUA UCA AAU UCU UAU UUG CCC CAU UUU UUU GGU UUA-BHQ-1 as substrate assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50183269(CHEMBL3818726)
Affinity DataEC50:  20nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085556(Oligoadenylate analogue | CHEMBL405496)
Affinity DataIC50: 24nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085557(Oligoadenylate analogue | CHEMBL407239)
Affinity DataEC50:  30nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50309128({[(2R,3R,4R,5R)-4-[({[(2R,3S,4R,5R)-5-(6-amino-8-m...)
Affinity DataEC50: >50nMAssay Description:Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50309127({[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)-5-(6-amino-8-m...)
Affinity DataEC50: >50nMAssay Description:Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50388145(CHEMBL2057900)
Affinity DataEC50:  53nMAssay Description:Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085555(Oligoadenylate analogue | CHEMBL384725)
Affinity DataIC50: 57nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50183278(CHEMBL3819262)
Affinity DataEC50:  84nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50085559(Oligoadenylate analogue | CHEMBL410213)
Affinity DataIC50: 105nMAssay Description:Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease LMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50183268(CHEMBL3818137)
Affinity DataEC50:  134nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2017
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50388159(CHEMBL2058187)
Affinity DataEC50:  200nMAssay Description:Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50021104((2'-5'(pAris)3)
Affinity DataIC50: 210nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
Target2-5A-dependent ribonuclease(Human)
Lerner Research Institute

Curated by ChEMBL
LigandPNGBDBM50438546(CHEMBL2414865)
Affinity DataEC50:  241nMAssay Description:Activation of human recombinant RNase L endonuclease activity using 6-FAM-UUA UCA AAU UCU UAU UUG CCC CAU UUU UUU GGU UUA-BHQ-1 as substrate assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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