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TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50467836(CHEMBL4282264)
Affinity DataKd:  0.00128nMAssay Description:Binding affinity to human Biotin-Avi-P300 assessed as dissociation constant using Neutravidin as ligand measured by Surface Plasmon Resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607602(CHEMBL5220994)
Affinity DataIC50: 0.0794nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607596(CHEMBL5221053)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd:  0.120nMAssay Description:Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607597(CHEMBL5219157)
Affinity DataIC50: 0.126nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607593(CHEMBL5219693)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607595(CHEMBL5219030)
Affinity DataIC50: 0.158nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607601(CHEMBL5219667)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM764595(US20250257055, Example 33 | US20250263415, Example...)
Affinity DataIC50: 0.200nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

LigandPNGBDBM764596(US20250257055, Example 34 | US20250263415, Example...)
Affinity DataIC50: 0.200nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50622583(CHEMBL5413450)
Affinity DataEC50:  0.200nMAssay Description:Induction of p300 degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607599(CHEMBL5220732)
Affinity DataIC50: 0.251nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607598(CHEMBL5220447)
Affinity DataIC50: 0.251nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50622564(CHEMBL5438596)
Affinity DataEC50:  0.300nMAssay Description:Induction of p300 degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607600(CHEMBL5220956)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607589(CHEMBL5219678)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM764573(US20250257055, Example 10 | US20250263415, Example...)
Affinity DataIC50: 0.400nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

LigandPNGBDBM764594(US20250257055, Example 32 | US20250263415, Example...)
Affinity DataIC50: 0.400nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50580965(CHEMBL5090239)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of p300 (unknown origin) preincubated for 15 mins followed by addition of substrate [3H] Ac-CoA and measured after 60 mins by liquid scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50542055(CHEMBL4636118 | US11274090, Example 22 Isomer 2)
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to recombinant full length EP300 (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM764567(US20250257055, Example 4 | US20250263415, Example ...)
Affinity DataIC50: 0.5nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50580965(CHEMBL5090239)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of p300 (unknown origin) using histone H3 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate and [3H]Ac-CoA ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2 | ...)
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to recombinant full length EP300 (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50580965(CHEMBL5090239)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of p300 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50580962(CHEMBL5082755)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of p300 (unknown origin) preincubated for 15 mins followed by addition of substrate [3H] Ac-CoA and measured after 60 mins by liquid scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM764572(US20250257055, Example 9 | US20250263415, Example ...)
Affinity DataIC50: 0.600nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50622565(CHEMBL5439670)
Affinity DataEC50:  0.600nMAssay Description:Induction of p300 degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM764566(US20250257055, Example 3 | US20250263415, Example ...)
Affinity DataIC50: 0.600nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607585(CHEMBL5219512)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607600(CHEMBL5220956)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of full-length P300 (1 to 2414 residues) (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50622562(CHEMBL5412027)
Affinity DataEC50:  0.700nMAssay Description:Induction of p300 degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607586(CHEMBL5221030)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607588(CHEMBL5220546)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50622563(CHEMBL5405240)
Affinity DataEC50:  0.800nMAssay Description:Induction of p300 degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM764570(US20250257055, Example 7 | US20250263415, Example ...)
Affinity DataIC50: 0.900nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50506372(CHEMBL4475351)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of p300 (unknown origin) preincubated for 15 mins followed by addition of substrate [3H] Ac-CoA and measured after 60 mins by liquid scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM764593(US20250257055, Example 31 | US20250263415, Example...)
Affinity DataIC50: 1nMAssay Description:The HAT activity inhibitory ability of HAT inhibitors was evaluated using SensoLyte HAT(p300) Assay Kit (ANASPEC, AS-72172). Specifically, 7.5 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
Go to US Patent

TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607605(CHEMBL5219177)
Affinity DataIC50: 1nMAssay Description:Inhibition of full-length P300 (1 to 2414 residues) (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50607590(CHEMBL5220332)
Affinity DataIC50: 1nMAssay Description:Inhibition of full-length P300 (unknown origin) using ARTKQTARKSTGGKAPRKQLAGG-K(Biotin)-amide as substrate preincubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50506372(CHEMBL4475351)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of p300 (unknown origin) using histone H3 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate and [3H]acetyl-Co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50622581(CHEMBL5402691)
Affinity DataEC50:  1.10nMAssay Description:Induction of p300 degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50269847(CHEMBL4097025)
Affinity DataIC50: 1.20nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged P300 measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50269847(CHEMBL4097025)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to p300 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50631963(CHEMBL5409153)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to P300 bromodomain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50269849(CHEMBL4076748)
Affinity DataIC50: 1.30nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged P300 measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50602864(INOBRODIB | Inobrodib | Ccs 1477 | Ccs1477 | CCS-1...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to p300 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50506377(CHEMBL4567310)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of p300 (unknown origin) using histone H3 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate and [3H]acetyl-Co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50269849(CHEMBL4076748)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to p300 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50467836(CHEMBL4282264)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to human Biotin-Avi-P300 using Neutravidin as ligand measured by Surface Plasmon Resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase p300(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50622576(CHEMBL5405858)
Affinity DataEC50:  1.60nMAssay Description:Induction of p300 degradation in human RS4-11 cells incubated for 4 hrs by Western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
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