Compile Data Set for Download or QSAR
Report error Found 415 for UniProtKB: Q14654
LigandPNGBDBM50476002(CHEMBL217511)
Affinity DataEC50:  0.676nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475970(CHEMBL426334)
Affinity DataEC50:  0.912nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475995(CHEMBL218564)
Affinity DataEC50:  1nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475999(CHEMBL214561)
Affinity DataEC50:  1.20nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475981(CHEMBL413532)
Affinity DataEC50:  1.80nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475993(CHEMBL217810)
Affinity DataEC50:  2.80nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50118351(6-chloro-3-(1-methylcyclobutyl)-amino-4H-thieno[3,...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475995(CHEMBL218564)
Affinity DataEC50:  3.70nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475995(CHEMBL218564)
Affinity DataEC50:  3.72nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475953(CHEMBL384564)
Affinity DataEC50:  3.89nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50476020(CHEMBL217847)
Affinity DataEC50:  6nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127794(Furan-2-carboxylic acid [2-(2,2,2-trifluoro-1-hydr...)
Affinity DataEC50:  9nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475971(CHEMBL386363)
Affinity DataEC50:  9.80nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127806(3-Cyano-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluor...)
Affinity DataEC50:  12nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127798(Thiophene-2-carboxylic acid [2-(2,2,2-trifluoro-1-...)
Affinity DataEC50:  12nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475973(CHEMBL265269)
Affinity DataEC50:  14nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127801(N-[2-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-...)
Affinity DataEC50:  15nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475983(CHEMBL216766)
Affinity DataEC50:  17nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50476011(CHEMBL216284)
Affinity DataEC50:  18nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127768(N-[2-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-...)
Affinity DataEC50:  18nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475982(CHEMBL215375)
Affinity DataEC50:  19nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475997(CHEMBL386119)
Affinity DataEC50:  20nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475997(CHEMBL386119)
Affinity DataEC50:  20nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50062397(N''-cyano-N-(1,1-dimethylpropyl)-N'-pyridin-3-ylgu...)
Affinity DataEC50:  22nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475972(CHEMBL216546)
Affinity DataEC50:  22.9nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475972(CHEMBL216546)
Affinity DataEC50:  23nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127788(3-Methyl-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Affinity DataEC50:  23nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50475972(CHEMBL216546)
Affinity DataEC50:  23nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127793(Oxazole-5-carboxylic acid [2-(2,2,2-trifluoro-1-hy...)
Affinity DataEC50:  24nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50476003(CHEMBL426160)
Affinity DataEC50:  26.9nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475977(CHEMBL386582)
Affinity DataEC50:  26.9nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50062397(N''-cyano-N-(1,1-dimethylpropyl)-N'-pyridin-3-ylgu...)
Affinity DataKi:  27nMAssay Description:Binding affinity was determined by displacement of [3H]P1075 from its binding sites in canine cardiac membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50476003(CHEMBL426160)
Affinity DataEC50:  27nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50476013(CHEMBL261996)
Affinity DataEC50:  27nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475961(CHEMBL214841)
Affinity DataEC50:  27.5nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475991(CHEMBL320983)
Affinity DataEC50:  28nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475961(CHEMBL214841)
Affinity DataEC50:  28nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475966(CHEMBL384576)
Affinity DataEC50:  28nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475961(CHEMBL214841)
Affinity DataEC50:  29nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50476004(CHEMBL386323)
Affinity DataEC50:  30nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50044253(CHEMBL11684 | (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-...)
Affinity DataEC50:  35nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax spontaneous bladder contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
LigandPNGBDBM50475970(CHEMBL426334)
Affinity DataEC50:  35nMAssay Description:Activity against pig bladder KATP channel opening assessed as ability to relax field-stimulated pig detrusorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127792(3-Fluoro-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluo...)
Affinity DataEC50:  44nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127799(N-[2-(2,2,2-Trifluoro-1-hydroxy-1-trifluoromethyl-...)
Affinity DataEC50:  44nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127762(Cyclobutanecarboxylic acid [2-(2,2,2-trifluoro-1-h...)
Affinity DataEC50:  45nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50476002(CHEMBL217511)
Affinity DataEC50:  45.7nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127764(3-Methyl-but-2-enoic acid [2-(2,2,2-trifluoro-1-hy...)
Affinity DataEC50:  46nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50476002(CHEMBL217511)
Affinity DataEC50:  46nMAssay Description:Ability to open human urinary bladder Kir6.2 channel containing SUR2B in Ltk cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50127785(4-Bromo-N-[2-(2,2,2-trifluoro-1-hydroxy-1-trifluor...)
Affinity DataEC50:  47nMAssay Description:Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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