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TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 2nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 2.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630292(US12110276, Compound 49 | CHEMBL5408536)
Affinity DataIC50: 2.70nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50629172(CHEMBL5401444)
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50629170(CHEMBL5419829)
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630292(US12110276, Compound 49 | CHEMBL5408536)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 3.20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699467((S,E)-1-(3-(1-(Prop-1-en-1- ylsulfonyl)azetidin-3-...)
Affinity DataIC50: 3.40nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699408((E)-3-chloro-1-[3-[4-(hydroxymethyl)- 1-[4- (trifl...)
Affinity DataIC50: 3.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699395(cyclobuten-1-yl-[3-[4- (hydroxymethyl)-1-[4- (trif...)
Affinity DataIC50: 3.60nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 3.80nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50629174(CHEMBL5422959)
Affinity DataIC50: 4nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50629175(CHEMBL5400400)
Affinity DataIC50: 4nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699420(1-[3-[4-[(1R)-1,2-dihydroxyethyl]-1- [4- (trifluor...)
Affinity DataIC50: 4.60nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699377(1-[3-[4-[(1R)-1,2-dihydroxyethyl]-1- [4- (trifluor...)
Affinity DataIC50: 5.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699421(cyclobuten-1-yl-[3-[4-[(1R)-1,2- dihydroxyethyl]-1...)
Affinity DataIC50: 5.70nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699465((S)-1-(3-(1-(Prop-1-en-2- ylsulfonyl)azetidin-3-yl...)
Affinity DataIC50: 5.70nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50629173(CHEMBL5415215)
Affinity DataIC50: 6nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50629171(CHEMBL5416415)
Affinity DataIC50: 6nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD2 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699421(cyclobuten-1-yl-[3-[4-[(1R)-1,2- dihydroxyethyl]-1...)
Affinity DataIC50: 6nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50626279(CHEMBL5440009)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to SA sensor chip immobilized N-terminal avi-tagged biotinylated TEAD2 YAP binding domain (unknown origin) assessed as binding const...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699419(1-[3-[4-[(1S)-1,2-dihydroxyethyl]-1-[4- (trifluoro...)
Affinity DataIC50: 6.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699327(1-[3-[4-[(1R)-1,2-dihydroxyethyl]-1- [4- (trifluor...)
Affinity DataIC50: 7.20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699378(cyclobuten-1-yl-[3-[4-[(1S)-1,2- dihydroxyethyl]-1...)
Affinity DataIC50: 7.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699415(2-chloro-1-[3-[4-[(1S)-1,2- dihydroxyethyl]-1-[4- ...)
Affinity DataIC50: 7.80nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699416(2-chloro-1-[3-[4-[(1R)-1,2- dihydroxyethyl]-1-[4- ...)
Affinity DataIC50: 8nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699366(1-[3-[4-[(1R)-1,2-dihydroxyethyl]-1- [4-(pentafluo...)
Affinity DataIC50: 8nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699325(2-chloro-N-methyl-N-((1-(4- (trifluoromethoxy)phen...)
Affinity DataIC50: 8.20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699469(Cyclobut-1-en-1-yl(3-(1-(4- (trifluoromethoxy)phen...)
Affinity DataIC50: 8.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50630290(CHEMBL5438256)
Affinity DataIC50: 9nMAssay Description:Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM626324(US11787775, Compound 29 | 2-[[[4-cyano-7-(4-isopro...)
Affinity DataIC50: 10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626362(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM626358(2-[[[7-cyano-4-[4- (trifluoromethoxy)phenyl]-1,3-...)
Affinity DataIC50: 10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626324(US11787775, Compound 29 | 2-[[[4-cyano-7-(4-isopro...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699468((R,E)-1-(3-(1-(prop-1-en-1- ylsulfonyl)azetidin-3-...)
Affinity DataIC50: 10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

LigandPNGBDBM626350(2-[[[4-cyano-7-(4-isopropyl-2- thienyl)-2,3-dihyd...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626358(2-[[[7-cyano-4-[4- (trifluoromethoxy)phenyl]-1,3-...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699438((E)-4,4,4-trifluoro-N-[[4- (hydroxymethyl)-1-[4- (...)
Affinity DataIC50: 10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM626362(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626336(2-[[[4-fluoro-7-(4-isopropylphenyl)- 2,3-dihydrob...)
Affinity DataEC50: <10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699434(4-hydroxy-N-[[4-(hydroxymethyl)-1- [4- (trifluorom...)
Affinity DataIC50: 12nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699343((E)-3-chloro-N-[[4-(hydroxymethyl)-1- [4- (trifluo...)
Affinity DataIC50: 14nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699375((E)-4,4-difluoro-N-[[4- (hydroxymethyl)-1-[4- (tri...)
Affinity DataIC50: 14nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM699466((R)-1-(3-(1-(prop-1-en-2- ylsulfonyl)azetidin-3-yl...)
Affinity DataIC50: 15nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

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