Compile Data Set for Download or QSAR
Report error Found 1142 of affinity data for UniProtKB/TrEMBL: Q5BJF2
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50035105(Siramesine | Lu 28-179 | 1'-{4-[1-(4-fluorophenyl)...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to sigma2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50035105(Siramesine | Lu 28-179 | 1'-{4-[1-(4-fluorophenyl)...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50216056((N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to sigma-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50618023(CHEMBL5426155)
Affinity DataKi:  0.430nMAssay Description:Binding affinity to sigma2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to Sigma 2-receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349368(US10207991, Ex. Cpd. No. 11 | US10611728, Example ...)
Affinity DataKi:  0.440nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349518(US10207991, Ex. Cpd. No. 34 | US10611728, Example ...)
Affinity DataKi:  0.530nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349518(US10207991, Ex. Cpd. No. 34 | US10611728, Example ...)
Affinity DataKi:  0.530nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349518(US10207991, Ex. Cpd. No. 34 | US10611728, Example ...)
Affinity DataKi:  0.530nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50613240(CHEMBL5278003)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to sigma 2 receptor in human MCF7 cells assessed as displacement of compound by measuring inhibition constant of DTG incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50540826(CHEMBL4647871)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]-ditolylguanidine from human Sigma 2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349505(US10207991, Ex. Cpd. No. 20 | US10611728, Example ...)
Affinity DataKi:  0.670nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349505(US10207991, Ex. Cpd. No. 20 | US10611728, Example ...)
Affinity DataKi:  0.670nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349505(US10207991, Ex. Cpd. No. 20 | US10611728, Example ...)
Affinity DataKi:  0.670nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  0.680nMAssay Description:Binding affinity to sigma 2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50048866(1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronap...)
Affinity DataKi:  0.680nMAssay Description:Binding affinity to sigma2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50618030(CHEMBL5418939)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-1,3-di-O-tolylguanidine from human sigma 2 receptor/TMEM97 transfected in sigma 1 receptor knockout HEK293 cell membranes assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50618035(CHEMBL5395523)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-1,3-di-O-tolylguanidine from human sigma 2 receptor/TMEM97 transfected in sigma 1 receptor knockout HEK293 cell membranes assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  1.10nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  1.10nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349569(US10207991, Ex. Cpd. No. 87 | US10611728, Example ...)
Affinity DataKi:  1.10nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM489602(US10961249, Entry 13 | US20240300954, Entry 13)
Affinity DataIC50: 1.20nMAssay Description:A stock concentration of 5 nM 3H-1,3-di-(2-tolyl)guanidine (3H-DTG) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM489602(US10961249, Entry 13 | US20240300954, Entry 13)
Affinity DataIC50: 1.20nMAssay Description:A stock concentration of 5 nM 3H-1,3-di-(2-tolyl)guanidine (3H-DTG) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349570(US10207991, Ex. Cpd. No. 88 | US10611728, Example ...)
Affinity DataKi:  1.30nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349570(US10207991, Ex. Cpd. No. 88 | US10611728, Example ...)
Affinity DataKi:  1.30nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349570(US10207991, Ex. Cpd. No. 88 | US10611728, Example ...)
Affinity DataKi:  1.30nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349578(US10207991, Ex. Cpd. No. 103 | US10611728, Example...)
Affinity DataKi:  1.40nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50232709(CHEMBL4098442 | US11046670, Table 6.3)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50232709(CHEMBL4098442 | US11046670, Table 6.3)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349578(US10207991, Ex. Cpd. No. 103 | US10611728, Example...)
Affinity DataKi:  1.40nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349578(US10207991, Ex. Cpd. No. 103 | US10611728, Example...)
Affinity DataKi:  1.40nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM489603(US10961249, Entry 14 | US20240300954, Entry 14)
Affinity DataIC50: 1.5nMAssay Description:A stock concentration of 5 nM 3H-1,3-di-(2-tolyl)guanidine (3H-DTG) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM489603(US10961249, Entry 14 | US20240300954, Entry 14)
Affinity DataIC50: 1.5nMAssay Description:A stock concentration of 5 nM 3H-1,3-di-(2-tolyl)guanidine (3H-DTG) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349387(US10207991, Ex. Cpd. No. 18 | US10611728, Example ...)
Affinity DataKi:  1.5nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349387(US10207991, Ex. Cpd. No. 18 | US10611728, Example ...)
Affinity DataKi:  1.5nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349387(US10207991, Ex. Cpd. No. 18 | US10611728, Example ...)
Affinity DataKi:  1.5nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM85609((R)-1-(2-(1-(3-methoxy-benzenesulfonyl)-pyrrolidin...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to sigma 2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349577(US10207991, Ex. Cpd. No. 102 | US10611728, Example...)
Affinity DataKi:  1.80nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM350897(US9796672, Example Compound 19)
Affinity DataKi:  1.80nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349478(US10207991, Ex. Cpd. No. 19 | US10611728, Example ...)
Affinity DataKi:  1.80nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349577(US10207991, Ex. Cpd. No. 102 | US10611728, Example...)
Affinity DataKi:  1.80nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349577(US10207991, Ex. Cpd. No. 102 | US10611728, Example...)
Affinity DataKi:  1.80nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349478(US10207991, Ex. Cpd. No. 19 | US10611728, Example ...)
Affinity DataKi:  1.80nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM50216057(N-[6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl-b...)
Affinity DataKi:  2nMAssay Description:Binding affinity to sigma 2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM489593(US10961249, Entry 4 | US11220505, Entry 2 | US2024...)
Affinity DataIC50: 2nMAssay Description:A stock concentration of 5 nM 3H-1,3-di-(2-tolyl)guanidine (3H-DTG) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM489593(US10961249, Entry 4 | US11220505, Entry 2 | US2024...)
Affinity DataIC50: 2nMAssay Description:A stock concentration of 5 nM 3H-1,3-di-(2-tolyl)guanidine (3H-DTG) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

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