Compile Data Set for Download or QSAR
Report error Found 1045 of affinity data for UniProtKB/TrEMBL: Q8TDS4
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23525(2-{3-[2-(2-chloro-4-hydroxyphenyl)-1,3-thiazol-5-y...)
Affinity DataIC50: 1nM EC50:  6nMpH: 7.4 T: 2°CAssay Description:Membranes were incubated in binding buffer with [5, 6-3H]-niacin in the presence of test compound. After 4 hours at room temperature, reactions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2008
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277718(2-(3-(7-hydroxypyrazolo[1,5-a]quinolin-3-yl)propan...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277717(2-(3-(6-chloro-7-hydroxynaphtho[2,1-d]isoxazol-3-y...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23525(2-{3-[2-(2-chloro-4-hydroxyphenyl)-1,3-thiazol-5-y...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50384640(CHEMBL2036954)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50342524((S)-2-(2-amino-3-(3-(5-hydroxypyridin-2-yl)-1,2,4-...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50313984(2-(2,2,3,3-tetrafluoro-3-(3-(5-hydroxypyridin-2-yl...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50384612(CHEMBL2036958)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50313977(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277715(2-(3-(7-hydroxynaphtho[2,1-d]isoxazol-3-yl)propana...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50313977(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277581(2-(3-(7-hydroxynaphtho[2,1-d]isoxazol-3-yl)propana...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50384637(CHEMBL2036951)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319102(5-(3,5-difluorophenyl)-2-(3-(6-hydroxynaphthalen-2...)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277714(2-(3-(7-hydroxy-4,5-dihydronaphtho[2,1-d]isoxazol-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23533(2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277580(2-(3-(7-hydroxy-4,5-dihydronaphtho[2,1-d]isoxazol-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319109(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50384634(CHEMBL2036948)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50313977(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50313976(2-({3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50342525((R)-2-(2-amino-3-(3-(5-hydroxypyridin-2-yl)-1,2,4-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23520(2-{3-[4-(2-chloro-4-hydroxyphenyl)phenyl]propanami...)
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]niacin from GRP109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23533(2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataIC50: 4nM EC50:  27nMpH: 7.4 T: 2°CAssay Description:Membranes were incubated in binding buffer with [5, 6-3H]-niacin in the presence of test compound. After 4 hours at room temperature, reactions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2008
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23520(2-{3-[4-(2-chloro-4-hydroxyphenyl)phenyl]propanami...)
Affinity DataIC50: 4nM EC50:  45nMpH: 7.4 T: 2°CAssay Description:Membranes were incubated in binding buffer with [5, 6-3H]-niacin in the presence of test compound. After 4 hours at room temperature, reactions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2008
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50384641(CHEMBL2036955)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319241(5-(3,5-difluorophenyl)-2-(3-(1-(5-hydroxypyridin-2...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]niacin from GRP109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277579(2-(3-(7-hydroxy-2H-benzo[g]indazol-3-yl)propanamid...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50342527((S)-2-(2-amino-3-(3-(5-hydroxypyridin-2-yl)-1,2,4-...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50384636(CHEMBL2036950)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277753(2-[3-(7-Hydroxy-benzo[d]imidazo[2,1-b]thiazol-2-yl...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319261(2-(3-(1-(5-hydroxypyridin-2-yl)-1H-pyrazol-3-yl)pr...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]niacin from GRP109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277716(2-(3-(6-fluoro-7-hydroxynaphtho[2,1-d]isoxazol-3-y...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319123((4S,5R)-2-(3-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadi...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319247(4-(2,3-difluorophenyl)-2-(3-(1-(5-hydroxypyridin-2...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]niacin from GRP109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23525(2-{3-[2-(2-chloro-4-hydroxyphenyl)-1,3-thiazol-5-y...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human recombinant GPR109A receptor expressed in CHO-K1 cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319096(5-butyl-2-(3-(6-hydroxynaphthalen-2-yl)propanamido...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23533(2-{3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319112((4S,5R)-2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxad...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277715(2-(3-(7-hydroxynaphtho[2,1-d]isoxazol-3-yl)propana...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50384644(CHEMBL2036960)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319110(5-(3-fluorophenyl)-2-(3-(3-(5-hydroxypyridin-2-yl)...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319252(2-(3-(1-(5-hydroxypyridin-2-yl)-5-methyl-1H-pyrazo...)
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]niacin from GRP109A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319100(5-(3-fluorophenyl)-2-(3-(6-hydroxynaphthalen-2-yl)...)
Affinity DataIC50: 7.40nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50313978(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM23524(2-{3-[5-(2-chloro-4-hydroxyphenyl)thiophen-2-yl]pr...)
Affinity DataIC50: 8nM EC50:  77nMpH: 7.4 T: 2°CAssay Description:Membranes were incubated in binding buffer with [5, 6-3H]-niacin in the presence of test compound. After 4 hours at room temperature, reactions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2008
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50271314(2-(3-(6-hydroxynaphthalen-2-yl)propanamido)cyclohe...)
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50313978(2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50319113((4S,5R)-5-(3-fluorophenyl)-2-(3-(3-(5-hydroxypyrid...)
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM50277633(2-(3-(7-hydroxy-[1,2,3]triazolo[1,5-a]quinolin-3-y...)
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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