Compile Data Set for Download or QSAR
Report error Found 131 of affinity data for UniProtKB/TrEMBL: Q9HCE7
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239101BDBM239101(US9403810, 2.2 | US10195181, Example 2.2)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239101BDBM239101(US9403810, 2.2 | US10195181, Example 2.2)
Affinity DataIC50: 0.900nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239101BDBM239101(US9403810, 2.2 | US10195181, Example 2.2)
Affinity DataIC50: 0.900nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193010BDBM50193010(CHEMBL3949800)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239132BDBM239132(US9403810, 22c)
Affinity DataIC50: 1.40nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239117BDBM239117(US9403810, 22 | US10195181, Example 22c)
Affinity DataIC50: 1.40nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239094BDBM239094(US9403810, 1.3 | US10195181, Example 1.3)
Affinity DataIC50: 1.80nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239094BDBM239094(US9403810, 1.3 | US10195181, Example 1.3)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239094BDBM239094(US9403810, 1.3 | US10195181, Example 1.3)
Affinity DataIC50: 1.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239092BDBM239092(US9403810, 1.1 | US10195181, Example 1.1)
Affinity DataIC50: 2.10nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239092BDBM239092(US9403810, 1.1 | US10195181, Example 1.1)
Affinity DataIC50: 2.10nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239099BDBM239099(US9403810, 2 | US10195181, Example 2)
Affinity DataIC50: 2.5nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239099BDBM239099(US9403810, 2 | US10195181, Example 2)
Affinity DataIC50: 2.5nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50193011BDBM50193011(CHEMBL3945602)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239091BDBM239091(US9403810, 1 | US10195181, Example 1)
Affinity DataIC50: 2.80nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239091BDBM239091(US9403810, 1 | US10195181, Example 1)
Affinity DataIC50: 2.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239095BDBM239095(US9403810, 1.4 | US10195181, Example 1.4)
Affinity DataIC50: 3.20nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239095BDBM239095(US9403810, 1.4 | US10195181, Example 1.4)
Affinity DataIC50: 3.20nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239105BDBM239105(US9403810, 6 | US10195181, Example 6)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239105BDBM239105(US9403810, 6 | US10195181, Example 6)
Affinity DataIC50: 5.70nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239105BDBM239105(US9403810, 6 | US10195181, Example 6)
Affinity DataIC50: 5.70nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239096BDBM239096(US9403810, 1.5 | US10195181, Example 1.5)
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239096BDBM239096(US9403810, 1.5 | US10195181, Example 1.5)
Affinity DataIC50: 6nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239102BDBM239102(US9403810, 3 | US10195181, Example 3)
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239102BDBM239102(US9403810, 3 | US10195181, Example 3)
Affinity DataIC50: 6nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239097BDBM239097(US9403810, 1.6 | US10195181, Example 1.6)
Affinity DataIC50: 8nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239097BDBM239097(US9403810, 1.6 | US10195181, Example 1.6)
Affinity DataIC50: 8nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622684BDBM50622684(CHEMBL5413507)
Affinity DataIC50: 11nMAssay Description:Inhibition of SMURF1 (unknown origin) assessed as self-ubiquitination by TR-FRET/biochemical assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239093BDBM239093(US9403810, 1.2 | US10195181, Example 1.2)
Affinity DataIC50: 14nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239093BDBM239093(US9403810, 1.2 | US10195181, Example 1.2)
Affinity DataIC50: 14nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239107BDBM239107(US9403810, 7 | US10195181, Example 7)
Affinity DataIC50: 19nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239107BDBM239107(US9403810, 7 | US10195181, Example 7)
Affinity DataIC50: 19nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239106BDBM239106(US9403810, 6.1 | US10195181, Example 6.1)
Affinity DataIC50: 23nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239106BDBM239106(US9403810, 6.1 | US10195181, Example 6.1)
Affinity DataIC50: 23nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622681BDBM50622681(CHEMBL5440935)
Affinity DataIC50: 29nMAssay Description:Inhibition of SMURF1 (unknown origin) assessed as self-ubiquitination by TR-FRET/biochemical assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239098BDBM239098(US9403810, 1.7 | US10195181, Example 1.7)
Affinity DataIC50: 33nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239098BDBM239098(US9403810, 1.7 | US10195181, Example 1.7)
Affinity DataIC50: 33nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 331990BDBM331990(US10195181, Example 16 | 5-((2S,6R)-6-(tert-butyl)...)
Affinity DataIC50: 37nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239126BDBM239126(US9403810, 16)
Affinity DataIC50: 37nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239108BDBM239108(US9403810, 8 | US10195181, Example 8)
Affinity DataIC50: 46nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239108BDBM239108(US9403810, 8 | US10195181, Example 8)
Affinity DataIC50: 46nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239110BDBM239110(US9403810, 10 | US10195181, Example 10)
Affinity DataIC50: 50nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239110BDBM239110(US9403810, 10 | US10195181, Example 10)
Affinity DataIC50: 50nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 238981BDBM238981(US9403833, 16)
Affinity DataIC50: 55nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239109BDBM239109(US9403810, 9 | US10195181, Example 9)
Affinity DataIC50: 58nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239109BDBM239109(US9403810, 9 | US10195181, Example 9)
Affinity DataIC50: 58nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239100BDBM239100(US9403810, 2.1 | US10195181, Example 2.1)
Affinity DataIC50: 64nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 239100BDBM239100(US9403810, 2.1 | US10195181, Example 2.1)
Affinity DataIC50: 64nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 239120BDBM239120(US9403810, 25d)
Affinity DataIC50: 74nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 332005BDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)
Affinity DataIC50: 74nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

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