BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.9M data for 1.2M Compounds and 9.3K Targets. Of those, 1,352K data for 627K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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18 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
A FRET-Based Assay for the Identification and Characterization of Cereblon Ligands.EBI
Max Planck Institute For Developmental Biology
Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.EBI
St. Jude Children'S Research Hospital
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.EBI
Dana-Farber Cancer Institute
Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase.EBI
Astrazeneca
Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay.EBI
Max Planck Institute For Developmental Biology
Ligand Design for Cereblon Based Immunomodulatory Therapy.EBI
Usona Institute
PROTAC Molecules for the Treatment of Autoimmune Disorders.EBI
Usona Institute
Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation.EBI
Shaoxing University
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders.EBI
TBA
Bound water molecules and conformational stabilization help mediate an antigen-antibody association.BDB
Institut Pasteur