PMID

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Article Title

Organization

Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.

Latvian Institute of Organic Synthesis

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.

Latvian Institute of Organic Synthesis

Protease inhibitors: current status and future prospects.

University of Queensland

alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.

Uppsala University

Expedient solid-phase synthesis of both symmetric and asymmetric diol libraries targeting aspartic proteases.

National University of Singapore

High antiplasmodial activity of novel plasmepsins I and II inhibitors.

University of Milan

Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations.

Uppsala University

Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.

LinköPing University

Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).

University of Zambia

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.

Latvian Institute of Organic Synthesis

2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity.

Latvian Institute of Organic Synthesis

Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands.

Novartis Pharmaceuticals

Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.

Abbott Laboratories

Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-Benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues.

Seoul National University

Identification of a high-affinity phosphopeptide inhibitor of Stat3.

The University of Texas At Houston