PMID

Data

Article Title

Organization

1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors.

Cephalon

Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.

Boehringer Ingelheim Pharmaceuticals

 

Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell culture

TBA

 

Peptidyl epoxides as inhibitors of α-chymotrypsin: Remarkable change from irreversible to reversible competitive inhibitor as a consequence of the improvement of binding affinity

TBA

 

Inactivation of serine protease, α-chymotrypsin by fluorinated phenylalanine analogues

TBA

 

N-(carbobenzyloxy)isatin: A slow binding α-keto lactam inhibitor of α-chymotrypsin

TBA

Inhibition of alpha-chymotrypsin with thiol-bearing substrate analogues in the presence of zinc ion.

Pohang University of Science and Technology

Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.

3-Dimensional Pharmaceuticals

The discovery of orally available thrombin inhibitors: optimisation of the P1 pharmacophore.

Novartis Horsham Research Centre

Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors.

Nippon Steel

Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams.

Boehringer Ingelheim (Canada)

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids.

Proscript

Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsin and elastase.

TBA

Enol lactone inhibitors of serine proteases. The effect of regiochemistry on the inactivation behavior of phenyl-substituted (halomethylene)tetra- and -dihydrofuranones and (halomethylene)tetrahydropyranones toward alpha-chymotrypsin: stable acyl enzyme intermediate.

TBA

Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.

Merrell Dow Research Institute