BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.9M data for 1.2M Compounds and 9.3K Targets. Of those, 1,352K data for 627K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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17 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Ras inhibition via direct Ras binding--is there a path forward?EBI
Genentech
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.EBI
Mirati Therapeutics
Discovery of Orally Bioavailable SOS1 Inhibitors for Suppressing KRAS-Driven Carcinoma.EBI
Wuhan University of Science and Technology
One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS.EBI
Boehringer Ingelheim Rcv
Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.EBI
Vanderbilt University School of Medicine
Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.EBI
Vanderbilt University School of Medicine
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.EBI
Boehringer Ingelheim Rcv
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.EBI
Vanderbilt University