PMID

Data

Article Title

Organization

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

University of Manchester

Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.

Dartmouth College

Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.

Università

Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.

National Center For Genetic Engineering and Biotechnology At Thailand

Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum.

National Center For Genetic Engineering and Biotechnology At Thailand

Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors.

Università

Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.

National Center For Genetic Engineering and Biotechnology At Thailand

Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.

East China University of Science and Technology

Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.

Pennsylvania State University