PMID

Data

Article Title

Organization

Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.

Xenon Pharmaceuticals

Endothelial lipase inhibitors for the treatment of atherosclerosis and cardiovascular disorders.

Therachem Research Medilab (India)

A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice.

Janssen Research and Development

Design and synthesis of boronic acid inhibitors of endothelial lipase.

Tufts University School of Medicine

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors.

Glaxosmithkline

Benzothiazole-based compounds as potent endothelial lipase inhibitors.

Bristol-Myers Squibb

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.

Bristol-Myers Squibb

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

Bristol-Myers Squibb

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

Bristol-Myers Squibb

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.

TBA

Benzopyrroloxazines containing a bridgehead nitrogen atom as promising scaffolds for the achievement of biologically active agents.

University of Calabria

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

Bristol-Myers Squibb

Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor acti

Bristol-Myers Squibb