PMID

Data

Article Title

Organization

Modeling, synthesis and biological activity of novel antifungal agents (1).

Nippon Roche Research Center

Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.

Act

Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).

Lek Pharmaceuticals

The biology and chemistry of hyperlipidemia.

Sinhgad College of Pharmacy

Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.

Swansea University

 

Synthesis and evaluation of photoaffinity probes directed at lanosterol 14α-demethylase (P-450_14DM)

TBA

Novel Aryl Alkamidazole Derivatives as Multifunctional Antifungal Inhibitors: Design, Synthesis, and Biological Evaluation.

Liaocheng University

Construction and activity evaluation of novel benzodioxane derivatives as dual-target antifungal inhibitors.

Liaocheng University

Design, Synthesis, and Biological Evaluation of Dual-Target COX-2/CYP51 Inhibitors for the Treatment of Fungal Infectious Diseases.

Liaocheng University

Efficient selective targeting of

University of Sharjah

Construction and activity evaluation of novel dual-target (SE/CYP51) anti-fungal agents containing amide naphthyl structure.

Liaocheng University

Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation.

Liaocheng University

Validation of Human Sterol 14?-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.

Vanderbilt University School of Medicine

32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis.

Institute

Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.

Syntex Discovery Research

Sterol 14?-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.

Vanderbilt University School of Medicine

Stereoisomers of ketoconazole: preparation and biological activity.

Syntex Research

[3H]TA-3090, a selective benzothiazepine-type calcium channel receptor antagonist: in vitro characterization.

Marion Merrell Dow