PMID

Data

Article Title

Organization

SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.

Institut Pasteur Hellenique

4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.

Lek Pharmaceuticals

A specific mechanism of nonspecific inhibition.

Northwestern University

Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.

F. Hoffmann-La Roche

Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.

Lek

 

The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins

TBA

 

Synthesis and biological activity of novel penem sulfoxides and sulfones

TBA

 

Inhibition of the RTEM-1 β-lactamase by boronic acids

TBA

TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases.

Chu Clermont-Ferrand

Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy.

Università

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.

Wyeth Research

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.

Wyeth Research

Mechanism of inactivation of beta-lactamases by novel 6-methylidene penems elucidated using electrospray ionization mass spectrometry.

Wyeth Research

Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.

Southern Methodist University

Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-?-lactamases.

Sichuan University

Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.

Wyeth-Ayerst Research

Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound.

University of Munich

Protein Stability Effects in Aggregate-Based Enzyme Inhibition.

University of California

?-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs.

Universidade De Santiago De Compostela

6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.

Wyeth-Ayerst Research

6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C beta-lactamases I.

Wyeth-Ayerst Research

Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-?-lactamases.

Sichuan University

Boron in drug design: Recent advances in the development of new therapeutic agents.

S£O Paulo State University

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-?-Lactamases.

University of Oxford

Synthesis and biological activity of 7-alkylidenecephems.

Southern Methodist University

SB-202742, a novel beta-lactamase inhibitor isolated from Spondias mombin.

Smithkline Beecham Pharmaceuticals

N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases.

Cnrs-Cercoa

Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.

TBA

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-?-lactamase Inhibitors.

University of Leeds