PMID

Data

Article Title

Organization

Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands.

Jagiellonian University Medical College

A monocyclic neodysiherbaine analog: Synthesis and evaluation.

Yokohama City University

Structural studies, homology modeling and molecular docking of novel non-competitive antagonists of GluK1/GluK2 receptors.

Medical University of Lublin

Ion channels as therapeutic targets: a drug discovery perspective.

Pfizer

Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.

University of Copenhagen

Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.

University Walk

Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.

Eli Lilly

4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.

Eli Lilly

Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors.

University of Bristol

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.

Novartis Pharma

Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.

University Walk

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.

Eli Lilly

Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.

The Danish University of Pharmaceutical Sciences

Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.

Central South University

Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.

The Danish University of Pharmaceutical Sciences

2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.

The Danish University of Pharmaceutical Sciences

Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).

The Danish University of Pharmaceutical Sciences

Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.

Abbott

4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.

Eli Lilly

Synthesis of a series of aryl kainic acid analogs and evaluation in cells stably expressing the kainate receptor humGluR6.

Eli Lilly

Allosteric control of an ionotropic glutamate receptor with an optical switch.

University of California Berkeley

Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin.

University of Thessaly