PMID

Data

Article Title

Organization

Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity.

Uppsala University

Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor.

Uppsala University

Dihydropyrimidine angiotensin II receptor antagonists.

Bristol-Myers Squibb Pharmaceutical Research Institute

 

1,4-substituted indoles: a potent and selective class of angiostensin II receptor antagonists

TBA

 

Acyliminothiadiazoline derivatives: New, highly potent, and orally active angiotensin II receptor antagonists

TBA

 

Uracil-based angiotensin II receptor antagonists

TBA

 

Discovery of nonpeptide potent conformationally restricted angiotensin II receptor antagonists

TBA

 

A potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist

TBA

 

Orally active prodrugs of quinoline-4-carboxylic acid angiotensin II receptor antagonists

TBA

 

Quinoline-4-carboxylic acids as angiotensin II receptor antagonists

TBA

 

Dihydro-imidazolone derivatives as angiotensin II receptor antagonists: chiral effect on the activity

TBA

 

Cyclopentanespiro-3H-dihydro-pyrimidinones as Angiotensin II AT₁ receptor antagonists

TBA

 

Triazolinones as nonpeptide angiotensin II antagonists. 2. discovery of a potent and orally active triazolinone acylsulfonamide

TBA

Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure.

Università

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.

Bristol-Myers Squibb Pharmaceutical Research Institute

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.

Warner-Lambert

Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.

Merck Research Laboratories

Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.

Searle

Synthesis and structure-activity relationships of nonpeptide, potent triazolone-based angiotensin II receptor antagonists.

Searle R&D

6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.

Dr. Karl Thomae

A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists.

Sanofi Recherche

Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.

E. Merck

Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists.

Carpibem

Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives.

Ciba-Geigy

Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1- yl]phenyl]methyl]imidazole derivatives and their in vitro activity.

Eli Lilly

Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.

Smithkline Beecham Pharmaceuticals

Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.

Abbott Laboratories