PMID

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Article Title

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Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

Duquesne University

A potent and selective inhibitor targeting human and murine 12/15-LOX.

University of California

Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes.

University of California

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.

Harvard Medical School

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.

National Institutes of Health

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

National Human Genome Research Institute

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

National Human Genome Research Institute

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Universidad De Santiago De Chile

Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.

University of California Santa Cruz

Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.

University of California Santa Cruz

Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells.

Albaha University

Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.

Osaka University

Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.

Yale University

Tetrazole hybrids with potential anticancer activity.

Henan University of Chinese Medicine

Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.

China Medical University

Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase.

Institute For Bio-Medical Research

Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Can

Eli Lilly