PMID

Data

Article Title

Organization

Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines.

Glaxosmithkline

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.

Astex Pharmaceuticals

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Glaxosmithkline

Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods.

Nippon Boehringer Ingelheim

The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.

Bristol-Myers Squibb

Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent.

Kanazawa University

Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.

University of North Carolina At Chapel Hill

In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.

Glaxosmithkline

Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.

Universit£Tsmedizin G£Ttingen

Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.

Novartis Institutes For Biomedical Research

Structure-based identification of OATP1B1/3 inhibitors.

Ku Leuven

Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

Pfizer

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

Kitasato University

Lead optimisation of pyrazoles as novel FPR1 antagonists.

Astrazeneca

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Uppsala University

Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver.

University Hospital

Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.

Bristol-Myers Squibb

Discovery of (

Bristol-Myers Squibb

Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.

Viiv Healthcare

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA

Bristol Myers Squibb

A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.

Merck

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.

Merck

Discovery of indoximod prodrugs and characterization of clinical candidate NLG802.

Newlink Genetics

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous

Agios Pharmaceuticals

Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors.

Gsk Pharmaceuticals R&D

Potent and Specific Inhibition of NTCP-Mediated HBV/HDV Infection and Substrate Transporting by a Novel, Oral-Available Cyclosporine A Analogue.

National Institute of Biological Sciences

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine ?-Secretase Modulator BMS-932481.

Bristol-Myers Squibb

Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development.

TBA

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.

Pfizer

Precursor-Directed Biosynthesis and Fluorescence Labeling of Clickable Microcystins.

University of Halle-Wittenberg

Discovery of AZD2716: A Novel Secreted Phospholipase A

Astrazeneca

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against

Glaxosmithkline

Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.

TBA

5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy.

Gsk Pharmaceuticals R&D

Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.

Glaxosmithkline

Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver.

University of Zurich

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.

Deutsches Krebsforschungszentrum

Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.

Kanazawa University

Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins.

Deutsches Krebsforschungszentrum

Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.

Chinese Academy of Sciences

Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects.

Atat£Rk University